PTEN、P53蛋白表达与甲状腺癌发生发展的关系  被引量:5

The Expression of PTEN and P53 Proteins in Thyroid Cancer and their Relationship with Tumorigenesis and Development

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作  者:李明[1] 许丽颖[1] 魏兰涛 LI Ming;XU Liying;WEI Lantao(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区:[1]郑州大学第一附属医院,450000

出  处:《实用癌症杂志》2021年第6期962-965,共4页The Practical Journal of Cancer

摘  要:目的探讨甲状腺癌组织中人第10号染色体缺失的磷酸酶(PTEN)、P53蛋白的表达及其意义。方法收集80例甲状腺癌组织及80例甲状腺良性肿瘤组织,应用免疫组化染色技术检测2组标本中的PTEN、P53蛋白表达情况,分析不同组织学类型、淋巴结转移、分化程度及TNM分期甲状腺癌组织中的PTEN、P53蛋白表达差异。结果甲状腺癌组织中的PTEN蛋白阳性表达率为68.75%、P53蛋白阳性表达率(63.75%)均高于良性组的15.00%、17.50%,具有统计学差异(P<0.05);在不同TNM分期、是否发生淋巴结转移的甲状腺癌组织中的PTEN蛋白阳性表达率具有统计学差异(P<0.05);是否发生淋巴结转移的甲状腺癌组织中P53蛋白阳性表达率具有统计学差异(P<0.05);甲状腺癌组织中的PTEN蛋白与P53蛋白阳性表达呈显著的正相关关系(Spearman秩相关系数=0.836,P<0.05)。结论甲状腺癌中PTEN、P53蛋白呈高表达较甲状腺良性肿瘤组织,并且与肿瘤的发生发展具有一定的密切关系。Objective To investigate the expression and significance of phosphatase(PTEN)and P53 protein deleted on chromosome 10 in thyroid cancer.Methods The expression of PTEN and P53 protein in 80 cases of thyroid cancer and 80 cases of benign thyroid tumors were detected by immunohistochemical staining.The differences of PTEN and P53 protein expression in different histological types,lymph node metastasis,differentiation degree and TNM stage of thyroid cancer were analyzed.Results The positive expression rates of PTEN protein and P53 protein in thyroid cancer tissues were 68.75%and 63.75%,respectively,higher than those in benign thyroid cancer tissues(15.00%and 17.50%,P<0.05).The positive expression rates of PTEN protein in thyroid cancer tissues with different TNM stages and lymph node metastasis were significantly different(P<0.05).The positive expression rate of P53 protein in adenocarcinoma tissues was significantly different(P<0.05).There was a significant positive correlation between PTEN protein and P53 protein expression in thyroid carcinoma(Spearman rank correlation coefficient=0.836,P<0.05).Conclusion The expression of PTEN and P53 protein in thyroid cancer is higher than that in benign thyroid tumors,and it is closely related to the occurrence and development of thyroid tumors.

关 键 词:甲状腺癌 PTEN蛋白 P53蛋白 

分 类 号:R736.2[医药卫生—肿瘤]

 

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