孕激素保守疗法对早期子宫内膜癌患者妊娠成功率及复发情况的影响  

Effect of Progesterone Conservative Therapy on the Pregnancy Success Rate and Recurrence of Patients with Early Endometrial Cancer

作　　者：刘光虹[1] LIU Guanghong(Zhengzhou People’s Hospital,Zhengzhou,450007)

机构地区：[1]郑州人民医院,450007

出　　处：《实用癌症杂志》2021年第6期1011-1013,共3页The Practical Journal of Cancer

摘　　要：目的探讨孕激素保守疗法对早期子宫内膜癌患者妊娠成功率及复发情况的影响。方法选择69例早期子宫内膜癌患者,按随机数表法分为2组。A组34例采用刮宫手术进行治疗,B组35例予以孕激素保守疗法治疗,连续治疗6个月。比较2组患者治疗6个月后疗效、治疗前及治疗6个月后激素受体评分(雌激素与孕激素)、炎性因子水平[白介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)]及随访12个月内妊娠、复发情况。结果治疗结束时,B组近期治疗总有效率(94.29%)高于A组(73.53%)(P<0.05)。治疗后,2组雌激素、孕激素受体评分较治疗前降低,B组低于A组(P<0.05);治疗后,2组IL-4、TNF-α较治疗前降低,B组低于A组(P<0.05)。随访至治疗后12个月,B组妊娠成功率(34.29%)高于A组(11.76%),复发率(6.06%)低于A组(36.00%)(P<0.05)。结论孕激素保守疗法治疗早期子宫内膜癌的近期疗效显著,可有效调节激素水平,减轻患者炎症反应,有助于妊娠成功率的提高及复发率的降低。Objective To investigate the effect of progesterone conservative therapy on the pregnancy success rate and recurrence of patients with early endometrial cancer.Methods 69 patients with early endometrial cancer were selected.Divided them into 2 groups according to the random number table method.34 cases in group A were treated with curettage,and 35 cases in group B were treated with progesterone conservative therapy,both were treated continuously for 6 months.Compared the efficacy after 6 months of treatment,the hormone receptor scores(estrogen and progesterone)before and after 6 months of treatment,inflammatory factor levels[interleukin-4(IL-4),tumor necrosis factor-α(TNF-α)]and pregnancy and recurrence within 12 months of follow-up of patients in the 2 groups.Results At the end of treatment,the total effective rate of recent treatment in group B(94.29%)was higher than that of group A(73.53%)(P<0.05).After treatment,the scores of estrogen and progesterone receptors in the 2 groups were decreased than those before treatment,and group B was lower than group A(P<0.05);after treatment,the levels of IL-4 and TNF-αin the 2 groups were decreased than those before treatment,and group B was lower than group A(P<0.05).Followed up to 12 months after treatment,the pregnancy success rate of group B(34.29%)was higher than that of group A(11.76%),and the recurrence rate(6.06%)was lower than that of group A(36.00%)(P<0.05).Conclusion Progesterone conservative therapy has a significant short-term efficacy in the treatment of early endometrial cancer.It can effectively regulate hormone levels,reduce the inflammatory response of patients,and is helpful to increase the pregnancy success rate and reduce the recurrence rate.

关 键 词：子宫内膜癌 刮宫手术 孕激素保守疗法 妊娠成功率 复发情况 

分 类 号：R737.33[医药卫生—肿瘤]