灵芝有效成分抗癫痫作用的生物学机制进展  

Biological mechanism progross of anti-epileptic effect of Ganoderma

作　　者：农雪娟 覃丽娜 赵爽[2] NONG Xuejuan;QIN Li’na;ZHAO Shuang(Department of Laboratory Medicine,Affiliated Hospital of Youjiang Medical University for Nationalities,Guangxi Zhuang Autonomous Region,Baise 533000,China;Preclinical Medicine College,Youjiang Medical University for Nationalities,Guangxi Zhuang Autonomous Region,Baise 533000,China)

机构地区：[1]右江民族医学院附属医院检验科,广西百色533000 [2]右江民族医学院基础医学院,广西百色533000

出　　处：《中国医药导报》2021年第18期36-39,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81760249);广西壮族自治区中医药管理局科研项目(GZZC2019143);广西研究生教育创新计划项目(JGY2018124);国家级大学生创新创业训练计划项目(201810599002、201710599004);广西自治区级大学生创新创业训练计划项目(201910599048);广西高等教育本科教学改革工程重点项目(2018JGZ131);广西职业教育教学改革研究项目(GXGZJG2019B180)。

摘　　要：癫痫的反复发作危害身心健康。灵芝主要含三萜类和多糖类、甾醇类、生物碱类、多肽氨基酸等药效成分,其抗癫痫作用可表现为通过抑制神经元凋亡、降低神经兴奋性、抗氧化应激、抑制炎症因子释放、调节神经递质平衡、促进神经元修复与突触重塑,提高学习记忆与认知功能,保护神经细胞,抑制神经元的癫痫样放电,抑制癫痫发作。开发传统抗癫痫药物与中药联合治疗,能够取长补短,使抗癫痫疗效更强,耐受性、安全性更好,以促进癫痫治疗的进步。Recurrent seizures of epilepsy are harmful to human health.Ganoderma mainly contains triterpenoids,polysaccharides,sterols,alkaloids,peptides and amino acids.Its antiepileptic effects can be manifested by inhibiting neuronal apoptosis,reducing nerve excitability,antioxidant stress,inhibiting the release of inflammatory factors,regulating the balance of neurotransmitters,promoting neuronal repair and synaptic remodeling,and improving learning,memory and cognitive functions,so protect nerve cells and inhibit seizure.The development of traditional antiepileptic drugs combined with traditional Chinese medicine can learn from each other’s strong points to make them more effective,more tolerable and safer,so as to promote the progress of epilepsy treatment,so that the antiepileptic effect is stronger,more tolerable and safer,to promote the progress of epilepsy treatment.

关 键 词：灵芝 癫痫 神经元凋亡 神经递质 

分 类 号：R749[医药卫生—神经病学与精神病学]