肠道菌群与双相障碍发病机制相关研究进展  

Progress in studies on the correlation between intestinal flora and the pathogenesis of bipolar disorder

作　　者：从痛快 潘苗[1] CONG Tongkuai;PAN Miao(The Second Department of Mood Disorders,the Second Affiliated Hospital of Xinxiang Medical University,He’nan Province,Xinxiang 453000,China)

机构地区：[1]新乡医学院第二附属医院心境障碍二科,河南新乡453000

出　　处：《中国医药导报》2021年第18期48-51,共4页China Medical Herald

基　　金：河南省医学科技攻关计划(联合共建)项目(LH GJ20190484)。

摘　　要：双相障碍是世界范围内导致经济负担和残疾的主要原因,但其潜在机制仍没有得到充分说明,治疗效果欠佳,易复发。近年来,肠道菌群在双相障碍中的作用越来越受到关注。双相障碍患者的肠道菌群发生变化,且其可通过免疫炎症反应、神经内分泌和神经系统等多种途径与大脑进行双向信息交流,引起情绪、精力水平和行为变化。因此,本文就肠道菌群与双相障碍发病机制的相关研究进展进行综述,为探究双相障碍的病因、诊断及鉴别诊断、治疗提供新思路。Bipolar disorder is a major cause of economic burden and disability worldwide,but its underlying pathogenesis is still poorly understood,treatment is less effective and relapse is more likely.In recent years,more and more attention has been paid to the role of intestinal flora in bipolar disorder.The intestinal flora of patients with bipolar disorder changes,and it has two-way communicate with the brain through a variety of pathways,including immune inflammatory response,neuroendocrinology and nervous system,causing mood,energy levels and behavioral changes.Therefore,this paper reviews the research progress on intestinal flora and the pathogenesis of bipolar disorder,and provides new ideas for exploring the etiology,diagnosis,differential diagnosis and treatment of bipolar disorder.

关 键 词：双相障碍 肠道菌群 微生物-肠-脑轴 

分 类 号：R749[医药卫生—神经病学与精神病学]