晚期NSCLC患者血清8-OHdG与放化疗联合治疗近期疗效相关性分析  

Analysis on the correlation of serum 8-OHdG in patients with advanced NSCLC with the short-term efficacy of combined radiotherapy and chemotherapy

作　　者：刘晓霞[1] 郭旭丽 苏镇军 贾金海[3] 段晓辉[2] 贺晓磊 吕林林 王平 李卫霞[1] 李志加 王云晓 LIU Xiaoxia;GUO Xuli;SU Zhenjun;JIA Jinhai;DUAN Xiaohui;HE Xiaolei;LYU Linlin;WANG Ping;LI Weixia;LI Zhijia;WANG Yunxiao(Medical College of Hebei University of Engineering,Handan 056038,Hebei,China;The Affiliated Hospital of Hebei University of Engineering,Handan 056002,Hebei,China;Hebei Medical University,Shijiazhuang 050017,Hebei,China)

机构地区：[1]河北工程大学医学院,河北邯郸056038 [2]河北工程大学附属医院,河北邯郸056002 [3]河北医科大学,河北石家庄050017

出　　处：《现代中西医结合杂志》2021年第18期1978-1981,1986,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：河北省科技支撑项目(18277703D)。

摘　　要：目的探讨放化疗联合治疗对晚期非小细胞肺癌(NSCLC)患者血清8-羟基脱氧鸟苷(8-OHdG)水平的影响及其与放化疗联合治疗近期疗效的相关性。方法选择2018年1—12月河北工程大学附属医院肿瘤科收治的87例晚期NSCLC患者作为患者组,选择同期健康体检者80例作为对照组。采集对照组和患者组放疗前、放疗15次、放疗30次、放疗后第4周空腹外周静脉血,采用ELISA法检测血清8-OHdG水平,分析放化疗联合治疗对血清8-OHdG水平的影响及其与近期疗效的相关性。结果患者组不同时间点血清8-OHdG水平均显著高于对照组(P均<0.05);放疗15次和放疗30次患者血清8-OHdG水平显著高于放疗前和放疗后第4周(P均<0.05),但放疗15次和放疗30次时比较、放疗后第4周与放疗前比较,差异均无统计学意义(P均>0.05);疾病理展(PD)患者放疗不同时间点血清8-OHdG水平均显著高于同期部分缓解(PR)和疾病稳定(SD)患者(P均<0.05),后两者之间比较差异均无统计学意义(P均>0.05),血清8-OHdG水平与放化疗联合治疗近期疗效呈负相关(r=-0.465,P<0.05);患者放化疗联合治疗近期疗效受KPS评分、肿瘤大小、病理分级、TNM分期和血清8-OHdG水平的影响(P均<0.05),血清8-OHdG是影响近期疗效的危险因素[HR=1.053,95%CI(1.007,1.101),P<0.05]。结论血清8-OHdG在晚期NSCLC患者中呈高表达,放化疗联合治疗可使其水平升高,其与近期疗效呈负相关,可作为预测放化疗近期疗效的指标。Objective It is to investigate the effect of combined radiotherapy and chemotherapy on the level of serum 8-hydroxydeoxyguanosine(8-OHdG)in patients with advanced non-small cell lung cancer(NSCLC)and its correlation with the short-term efficacy of combined radiotherapy and chemotherapy.Methods Eighty-seven patients with advanced NSCLC admitted to the Department of Oncology of Affiliated Hospital of Hebei University of Engineering from January to December 2018 were selected as the patient group,and 80 healthy patients during the same period were selected as the control group.The fasting peripheral venous blood was collected before radiotherapy,after 15,30 times of radiotherapy,and 4 weeks after radiotherapy in the control group and the patient group.The serum 8-OHdG level was detected by ELISA,and the effect of combined radiotherapy and chemotherapy on serum 8-OHdG level and its correlation with short-term efficacy was analyzed.Results The serum 8-OHdG levels of the patient group at different time points were significantly higher than those of the control group(all P<0.05);the serum 8-OHdG levels of the patients after 15 and 30 times of radiotherapy were significantly higher than those before and 4 weeks after radiotherapy(all P<0.05),but there was no significant difference between 15 times of radiotherapy and 30 times of radiotherapy,and between the 4th week after radiotherapy and before radiotherapy(all P>0.05);the serum 8-OHdG levels in progressive disease(PD)patients at different time points of radiotherapy were significantly higher than those of partial r esponse(PR)and stable disease(SD)patients in the same period(all P<0.05),and there was no significant difference between the latter two ones(both P>0.05).The serum 8-OHdG level was negatively correlated with the short-term efficacy of combined radiotherapy and chemotherapy(r=-0.465,P<0.05);the short-term curative effect of combined radiotherapy and chemotherapy was affected by KPS score,tumor size,pathological grade,TNM staging and serum 8-OHdG level(all P<0

关 键 词：晚期非小细胞肺癌 血清8-羟基脱氧鸟苷 放疗 近期疗效 预测指标 

分 类 号：R734.2[医药卫生—肿瘤]