血清低氧诱导因子-1α、表皮生长因子水平与老年帕金森病患者预后的相关性  

Correlation between serum hypoxia inducible factor-1αand epidermal growth factor levels and prognosis in elderly patients with Parkinson's disease

作　　者：郭刚 Guo Gang

机构地区：[1]驻马店市第一人民医院神经内科,463000

出　　处：《中国疗养医学》2021年第8期861-865,共5页Chinese Journal of Convalescent Medicine

摘　　要：目的观察老年帕金森病(Parkinson's disease,PD)患者预后与血清低氧诱导因子-1α(hypoxiainduciblefactor1α,HIF-1α)、表皮生长因子(epidermal growth factor,EGF)水平的关系,旨在指导未来老年PD患者预后风险评估与干预。方法前瞻性选取2018年6月至2019年10月来某院就诊的85例老年PD患者,在治疗前测定患者血清HIF-1α、EGF水平,调查患者基线资料,详细询问并记录患者的一般资料,并于治疗1年评估患者预后,分析血清HIF-1α、EGF水平与老年PD患者预后不良的关系。结果85例PD患者经治疗1年,Hoehn-Yahr分级1级8例,1.5级10例,2级13例,2.5级14例,3级18例,4级12例,5级10例,预后不良(3级+4级+5级)40例,占47.06%;预后不良患者血清HIF-1α水平高于预后良好患者,EGF水平低于预后良好患者,差异有统计学意义(P<0.05);经相关性分析结果显示,老年PD患者血清HIF-1α水平与EGF水平之间呈负相关(r<0,P<0.05);经二元Logistic回归分析后建立多元回归模型,结果显示,血清EGF低表达、HIF-1α过表达均是老年PD患者预后不良的风险因子(OR>1,P<0.05);绘制ROC曲线结果显示,老年PD患者治疗前的血清EGF、HIF-1α水平预测患者预后不良风险AUC均>0.80,预测价值均理想。结论老年PD患者治疗前血清EGF低表达、HIF-1α过表达均可能提示治疗后预后不良高风险,可将二者作为老年PD患者预后不良风险预测标志物。Objective To observe the correlation between prognosis and serum hypoxiainduciblefactor1α(HIF-1α)and epidermal growth factor(EGF)levels of elderly patients with Parkinson's disease(PD)so as to guide future prognostic risk assessment and intervention in elderly PD patients.Methods Eighty-five elderly PD patients admitted to a hospital from June 2018 to October 2019 were prospectively selected.Serum HIF-1αand EGF levels of the patients were measured before treatment,baseline data of the patients were investigated,general information was detailed and recorded,and prognosis of the patients was evaluated after 1 year of treatment.The correlation between serum HIF-1αand EGF levels and poor prognosis in elderly PD patients was analyzed.Results After 1 year of treatment,in 85 patients with PD,8 cases of Hoehn-Yahr Grade 1,10 cases of Grade 1.5,13 cases of Grade 2,14 cases of Grade 2.5,18 cases of Grade 3,12 cases of Grade 4,and 10 cases of Grade 5,40 cases(47.06%)had poor prognosis(Grade 3+4+5).The level of serum HIF-1αin patients with poor prognosis was higher than that in patients with good prognosis,and the level of serum EGF was lower than that in patients with good prognosis,with statistical significance(P<0.05).Correlation analysis showed that there was a negative correlation between serum HIF-1αand EGF in elderly PD patients(r<0,P<0.05).Multiple regression model was established after binary Logistic regression analysis.The results showed that both low expression of serum EGF and overexpression of HIF-1αwere risk factors for poor prognosis in elderly PD patients(OR>1,P<0.05).ROC curve results showed that serum levels of EGF and HIF-1αin elderly PD patients before treatment predicted the risk of poor prognosis of patients with AUC of>0.80,and the predictive value was all ideal.Conclusion Both low serum EGF expression and overexpression of HIF-1αin elderly PD patients before treatment may indicate a high risk of poor prognosis after treatment,which can be used as predictive markers of poor prognosis risk in

关 键 词：帕金森病 低氧诱导因子 表皮生长因子 预后 相关性 

分 类 号：R742.5[医药卫生—神经病学与精神病学]