黏着斑相关分子Talin在肿瘤中的作用  

The role of focal adhesion-related molecule Talin in tumors

作　　者：单政 王梓如 刘璐璐 鞠环宇[1] Shan Zheng;Wang Ziru;Liu Lulu;Ju Huanyu(Department of Immunology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学免疫教研室,150081

出　　处：《国际免疫学杂志》2021年第3期307-311,共5页International Journal of Immunology

基　　金：国家自然科学基金青年基金(81702900);黑龙江省博士后科研启动金(LBH-Q17115)。

摘　　要：目前肿瘤的恶性化是人类致死的重要病因,肿瘤细胞的不断浸润、转移是导致肿瘤恶性化的最主要因素之一。肿瘤细胞的迁移运动是一个相当复杂的进程,其主要受黏着斑(focal adhesions,FAs)的调控。黏着斑是由多分子构成的复合物,其中踝蛋白(Talin,TLN)作为黏着斑复合物的主要成分之一,是整合素(integrin)活化的重要调控蛋白。TLN能将整合素和胞内肌动蛋白(actin)两者联系起来,同时TLN还与细胞运动的调控息息相关。文章就TLN的结构、功能以及在细胞迁移和在肿瘤中的作用进行阐述。Malignant tumors are still the leading cause of death in humans.The continuous infiltration and metastasis of tumor cells are one of the most important causes of malignant tumor.However,the migration movement of tumor cells is a very complicated process,which is mainly controlled by focal adhesions(FAs).The focal adhesion is a complex composed of multiple molecules.As one of the main components of the focal adhesion complex,Talin(TLN)is an important regulatory protein for the activation of integrin.It can link both integrin and intracellular actin,and is also closely related to the regulation of cell movement.This rewiew summarized the structure,function,and role of TLN in cell migration and tumors.

关 键 词：黏着斑 踝蛋白 整合素激活 细胞迁移 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]