环状RNA ciRS-7的功能及调控机制研究进展  

Research progress on the function and regulatory mechanism of ciRS-7

作　　者：俞倩 蒉潇飞 李潇 周爽 Yu Qian;Kui Xiaofei;Li Xiao;Zhou Shuang(College of Acupuncture and Tuina,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学针灸推拿学院,201203

出　　处：《国际免疫学杂志》2021年第3期325-328,共4页International Journal of Immunology

基　　金：国家自然科学基金(81874505,81574059)。

摘　　要：ciRS-7是一种特殊的环状RNA分子,在哺乳动物和人类的细胞中大量存在,在基因的转录与翻译中起到重要作用进而参与调控多种生命活动。ciRS-7是近年来RNA领域最新的研究热点。ciRS-7通过调控多条信号通路在细胞中发挥特定作用,将细胞外的分子信号经细胞膜传入细胞内发挥效应。ciRS-7富含MicroRNA(miRNA)结合位点,在细胞中作为miRNA的分子海绵(miRNA sponge),通过竞争性结合miRNA,抑制miRNA的功能,进而发挥其在细胞中的功能。文章对ciRS-7在细胞中的功能及调控机制方面的最新国内外研究进展进行综述。ciRS-7 is a special circular RNA molecule,which is abundant in mammalian and human cells.It plays an important role in gene transcription and translation,and then participates in the regulation of a variety of life activities.ciRS-7 is the latest research hotspot in RNA field in recent years.It plays a specific role in cells by regulating multiple signaling pathways,and then transfers the extracellular molecular signals into the cell through the cell membrane.ciRS-7 is rich in MicroRNA(miRNA)binding sites,and acts as miRNA sponge in cells.Through competitive binding of miRNA,ciRS-7 inhibits the function of miRNA,and then plays its role in cells.This review summarized the latest research progress of ciRS-7 in cell function and regulatory mechanism.

关 键 词：ciRS-7 miRNA海绵 信号通路 细胞 

分 类 号：R363[医药卫生—病理学]