C反应蛋白单体在炎症-血栓网络中作用的研究进展  

Progress of monomeric C-reactive protein in the inflammatory-thrombotic network

作　　者：姜晓月 张文静[1] 查才军 刘彦虹[1] Jiang Xiaoyue;Zhang Wenjing;Zha Caijun;Liu Yanhong(Department of Clinical Laboratory,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院检验科,150086

出　　处：《国际免疫学杂志》2021年第3期351-354,共4页International Journal of Immunology

摘　　要：C反应蛋白(C-reactive protein,CRP)是一种急性时相反应蛋白。在急性炎症中,CRP的浓度可升高1000倍,高敏感性CRP水平升高是炎症和心血管疾病发生的独立标志物。循环的CRP以正五聚体(pentameric CRP,pCRP)的形式存在,在炎症条件下,解离成单体CRP(monomeric CRP,mCRP)。mCRP是介导机体炎性反应的主要执行者,在炎症和动脉粥样硬化血栓形成中发挥重要作用。文章将mCRP在炎症-血栓网络中的最新研究进展进行综述。C-reactive protein(CRP)is an acute phase reactant.In acute inflammation,the concentration of CRP can be increased 1000 times.The high sensitive CRP level is utilized as an independent biomarker of inflammation and cardiovascular disease.Circulating CRP exists in the form of pentameric CRP(pCRP),and dissociated into monomeric CRP(mCRP)in inflammatory condition.mCRP is the main agent to mediate the body's inflammatory response and plays an important role in inflammation and atherosclerotic thrombosis.This review summarized the latest research progress of mCRP in the inflammation-thrombus network.

关 键 词：C反应蛋白 C反应蛋白单体 动脉粥样硬化 炎症 血栓 

分 类 号：R364.5[医药卫生—病理学]