T淋巴细胞亚群在非酒精性脂肪性肝病恶性转化中的作用机制  

Mechanism of T lymphocyte subsets in the malignant transformation of non-alcoholic fatty liver disease

作　　者：叶文欣 刘莹 汪晓莺 姚登福[2] 姚敏 Ye Wenxin;Liu Ying;Wang Xiaoying;Yao Dengfu;Yao Min(Department of Immunology,Medical School of Nantong University,Jiangsu 226001;Affiliated Hospital of Nantong University,Jiangsu 226001)

机构地区：[1]南通大学医学院免疫学系,江苏南通226001 [2]南通大学附属医院,江苏南通226001

出　　处：《中华肝脏病杂志》2021年第6期595-599,共5页Chinese Journal of Hepatology

基　　金：国家自然科学基金面上项目(31872738);江苏省重点研发计划(社会发展)项目(BE2016698);南通市科技计划基础医学重点研究专项(MS12020021)。

摘　　要：非酒精性脂肪性肝病正成为全球肝病相关发病率和病死率的主要原因,其病理学机制复杂,尚未完全清楚,免疫调节无疑是其发病过程中的重要环节,尤其T淋巴细胞亚群变化。现介绍T淋巴细胞参与脂肪变性、炎症、纤维化、恶性转化及免疫治疗的研究进展。Nonalcoholic fatty liver disease is becoming the main cause of global liver disease-related morbidity and mortality.Notably,its pathological mechanism is complicated and not yet fully understood.Therefore,immune regulation is undoubtedly an important link in its pathogenesis,especially the change of T lymphocyte subsets.This article introduces the research progress of T lymphocytes involved in steatosis,inflammation,fibrosis,malignant transformation and immunotherapy.

关 键 词：非酒精性脂肪性肝病 T淋巴细胞 慢性肝病 CD分子 

分 类 号：R575.5[医药卫生—消化系统]