肿瘤新型显像剂^(68)Ga-FAPIs的研究进展  

Research progress of new tumor imaging agent^(68)Ga-FAPIs

作　　者：王婧伊 杨卫东 汪静 Wang Jingyi;Yang Weidong;Wang Jing(Department of Nuclear Medicine,1st Affiliated Hospital of Fourth Military Medical University,Xi′an 710032,China)

机构地区：[1]空军军医大学第一附属医院核医学科,西安710032

出　　处：《中华核医学与分子影像杂志》2021年第6期374-377,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金(91959208,81971646)。

摘　　要：^(18)F-脱氧葡萄糖(FDG)是目前最常用的广谱肿瘤显像剂,但在某些肿瘤的应用上存在一定的局限性。成纤维细胞激活蛋白(FAP)选择性地表达于90%以上的恶性上皮肿瘤,而在正常组织及良性肿瘤中几乎不表达,成纤维细胞激活蛋白抑制剂(FAPIs)可与FAP特异性结合,选择性地靶向FAP阳性的组织。核素标记FAPIs,如^(68)Ga-FAPIs在肿瘤显像中具有安全可靠、组织本底低等特点,并能对多种实体瘤进行显像,有望作为新的肿瘤广谱显像剂在临床应用发挥更大作用。该文就国内外FAPIs在肿瘤显像及诊断的最新进展做一综述。^(18)F-fluorodeoxyglucose(FDG)is the most commonly used broad-spectrum tumor imaging agent,but there are certain limitations in the application of some tumors.Fibroblast activation protein(FAP)is selectively expressed in more than 90%of malignant epithelial tumors,while it is hardly expressed in normal tissues and benign tumors.FAP inhibitors(FAPIs)specifically bind to FAP and selectively target FAP-positive tissues.In recent years,it has been reported that radionuclide-labeled FAPIs,such as ^(68)Ga-FAPIs,are safe and reliable in tumor imaging and have low tissue background.They can also be used to image a variety of solid tumors,which are expected to be new tumor broad-spectrum imaging agents and play a greater role in clinical applications.This article reviews the recent progress of FAPIs in tumor imaging and diagnosis at home and abroad.

关 键 词：喹啉类 镓放射性同位素 正电子发射断层显像术 发展趋势 

分 类 号：R730.4[医药卫生—肿瘤]