The anti-inflammatory astrocyte revealed:the role of the microbiome in shaping brain defences  

作　　者：Alexei Verkhratsky Peter Illes Yong Tang Alexey Semyanov 

机构地区：[1]Faculty of Biology,Medicine and Health,The University of Manchester,Manchester,UK [2]Achucarro Center for Neuroscience,IKERBASQUE,Basque Foundation for Science,48011 Bilbao,Spain&Department of Neurosciences,University of the Basque Country UPV/EHU and CIBERNED,Leioa,Spain [3]Sechenov First Moscow State Medical University,Moscow,Russia [4]School of Acupuncture and Tuina and International Collaborative Centre on Big Science Plan for Purinergic Signalling,Chengdu University of Traditional Chinese Medicine,Chengdu,China [5]Rudolf Boehm Institute for Pharmacology and Toxicology,University of Leipzig,Leipzig,Germany [6]Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry,Russian Academy of Sciences,Moscow,117997,Russia [7]Faculty of Biology,Moscow State University,Moscow,Russia

出　　处：《Signal Transduction and Targeted Therapy》2021年第5期1404-1405,共2页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants of the National Key R&D Programme of China(2019YFC1709101);the Project First-Class Disciplines Development of Chengdu University of Traditional Chinese Medicine(CZYHW1901)awarded in order to build up the“International Collaborative Centre on Big Science Plan for Purinergic Signalling”,and the Science and Technology Programme of Sichuan Province,China(2019YFH0108);The stay and work of PI in Chengdu was supported by a grant from the State Administration of Foreign Experts Affairs(G20190236012);A.S.and Y.T.are supported by RFBR grant 21-54-53018 for the NSFC-RFBR project.

摘　　要：The paper,published recently in Nature by the group of Francisco Quintana,1 describes the anti-inflammatory astrocytes,activity of which is tuned by the microbiotome and meningeal natural killer(NK)cells.Astrocytes are a sub-type of neuroglia responsible for homoeostasis and defence of the nervous system.Pathological reactions of neuroglial cells in various neurological disorders have been identified and characterised in the end of the 19th century;in particular hypertrophy of astrocytes was recognised as a frequent morbid change accompanying diseases of the central nervous system(CNS).

关 键 词：inflammatory STASIS KILLER 

分 类 号：R338[医药卫生—人体生理学]