From purines to purinergic signalling:molecular functions and human diseases  

作　　者：Zhao Huang Na Xie Peter Illes Francesco Di Virgilio Henning Ulrich Alexey Semyanov Alexei Verkhratsky Beata Sperlagh Shu-Guang Yu Canhua Huang Yong Tang 

机构地区：[1]State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,and West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,and Collaborative Innovation Center for Biotherapy,Chengdu,China [2]International Collaborative Centre on Big Science Plan for Purinergic Signalling,Chengdu University of Traditional Chinese Medicine,Chengdu,China [3]Rudolf-Boehm-Institut für Pharmakologie und Toxikologie,Universitaet Leipzig,Leipzig,Germany [4]Department of Medical Sciences,University of Ferrara,Ferrara,Italy [5]Department of Biochemistry,Institute of Chemistry,University of São Paulo,São Paulo,Brazil [6]Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry,Russian Academy of Sciences,Moscow,Russia [7]Sechenov First Moscow State Medical University,Moscow,Russia [8]Faculty of Biology,Medicine and Health,The University of Manchester,Manchester,UK [9]Department of Pharmacology,Institute of Experimental Medicine,Hungarian Academy of Sciences,Budapest,Hungary [10]Acupuncture and Chronobiology Key Laboratory of Sichuan Province,Chengdu,China [11]School of Basic Medical Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第5期1463-1482,共20页信号转导与靶向治疗（英文）

基　　金：This article is dedicated to the memory of recently deceased Professor Geoffrey Burnstock.This work was supported by grants from National Key R&D Programme of China(2019YFC1709101,2020YFA0509400,2020YFC2002705);the National Natural Science Foundation of China(81821002,81790251,81373735,81972665);Guangdong Basic and Applied Basic Research Foundation(2019B030302012);the Project First-Class Disciplines Development of Chengdu University of Traditional Chinese Medicine(CZYHW1901);Sao Paulo Research Foundation(FAPESP 2018/07366-4);NSFC and RFBR(project number 21-54-53018,82111530059);MDT programme of State Administration of Traditional Chinese Medicine;Science and Technology Programme of Sichuan Province,China(2019YFH0108,2021JDGD0037).

摘　　要：Purines and their derivatives,most notably adenosine and ATP,are the key molecules controlling intracellular energy homoeostasis and nucleotide synthesis.Besides,these purines support,as chemical messengers,purinergic transmission throughout tissues and species.Purines act as endogenous ligands that bind to and activate plasmalemmal purinoceptors,which mediate extracellular communication referred to as“purinergic signalling”.Purinergic signalling is cross-linked with other transmitter networks to coordinate numerous aspects of cell behaviour such as proliferation,differentiation,migration,apoptosis and other physiological processes critical for the proper function of organisms.Pathological deregulation of purinergic signalling contributes to various diseases including neurodegeneration,rheumatic immune diseases,inflammation,and cancer.Particularly,gout is one of the most prevalent purine-related disease caused by purine metabolism disorder and consequent hyperuricemia.Compelling evidence indicates that purinoceptors are potential therapeutic targets,with specific purinergic agonists and antagonists demonstrating prominent therapeutic potential.Furthermore,dietary and herbal interventions help to restore and balance purine metabolism,thus addressing the importance of a healthy lifestyle in the prevention and relief of human disorders.Profound understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases.

关 键 词：METABOLISM DISEASES URINE 

分 类 号：O62[理学—有机化学]