脑卒中后抑郁患者大便标本检测中的微生物种群变化分布分析  

Analysis of Microbial Population Distribution in Stool Samples of Patients with Post-stroke Depression

作　　者：李延红[1] 周启宇 李盼盼 孙士宾 靳智凯 席子明[1] LI Yanhong;ZHOU Qiyu;LI Panpan;SUN Shibin;JIN Zhikai;XI Ziming(Department of General Medicine,the First Affiliated Hospital of Henan University,Kaifeng 475001,China;Clinical Medicine,North Sichuan Medical College,Nanchong 637199,China)

机构地区：[1]河南大学第一附属医院全科医学科,河南开封475001 [2]川北医学院临床医学,四川南充637199

出　　处：《河南医学研究》2021年第15期2724-2727,共4页Henan Medical Research

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20190530)。

摘　　要：目的分析脑卒中后抑郁患者大便标本检测中的微生物种群变化分布情况。方法选取河南大学第一附属医院2018年11月至2020年11月收治的76例脑卒中后抑郁症患者,将其设为观察组;选取同期在河南大学第一附属医院接受健康体检的76例健康体检者,将其设为对照组;对两组样品的微生物种群变化分布情况进行统计分析。结果在门水平以及属水平方面,两组样品的微生物群落结构及其相对丰度比较,差异有统计学意义(P<0.05)。除拟杆菌科外,两组样品的微生物群落结构及其相对丰度在科水平方面比较,差异有统计学意义(P<0.05)。结论脑卒中后抑郁患者大便标本的微生物种群分布存在较大的变化。Objective To analyze the change and distribution of microbial population in stool samples of patients with post-stroke depression.Methods A total of 76 patients with post-stroke depression in the First Affiliated Hospital of Henan University from November 2018 to November 2020 were selected as the experimental group.A total of 76 healthy people who received physical examination in the First Affiliated Hospital of Henan University during the same period were selected as the control group.The change and distribution of microbial population in the two groups were analyzed.Results At the phylum level and genus level,there were differences in microbial community structure and relative abundance between the two groups(P<0.05).Except bacteroideae,there were differences in microbial community structure and relative abundance between the two groups(P<0.05).Conclusion The distribution of microbial population in stool samples of patients with post-stroke depression has great changes.

关 键 词：微生物种群 大便标本 脑卒中 抑郁 

分 类 号：R743.3[医药卫生—神经病学与精神病学]