介入溶栓术治疗对超早期急性闭塞性脑梗死患者神经功能及生活质量恢复的影响  

Influence of Interventional Thrombolytic Therapy on the Recovery of Neurological Function and Quality of Life in Patients with Ultra-early Acute Occlusive Cerebral Infarction

作　　者：林进平[1] 黄瑞宏[1] 李文生[1] 李凯 刘琼 LIN Jinping;HUANG Ruihong;LI Wensheng;LI Kai;LIU Qiong(Sanming Second Hospital,Yong’an 366000,China)

机构地区：[1]三明市第二医院,福建永安366000

出　　处：《中外医学研究》2021年第16期67-70,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨介入溶栓术治疗对超早期急性闭塞性脑梗死患者神经功能及生活质量的影响。方法:选择本院2017年6月-2018年10月治疗的超早期急性闭塞性脑梗死患者62例为研究对象。将发病3 h以内治疗的患者作为观察组,将发病3 h及以上治疗的患者作为对照组,各31例。两组均进行介入溶栓术治疗,比较两组神经功能缺损评分、生活质量评分,以及血清B型钠尿肽(BNP)、同型半胱氨酸(Hcy)、过氧化物酶体增殖激活受体γ(PPARγ)水平与并发症发生率。结果:治疗后1、7、30 d,观察组神经功能缺损评分均低于对照组(P<0.05)。治疗后3 d,观察组心理健康、自我评价、社会功能、日常生活评分均高于对照组,差异有统计学意义(P<0.05);治疗后3 d,两组血清BNP、Hcy、PPARγ水平均较治疗前明显降低,且观察组血清BNP、Hcy、PPARγ水平低于对照组(P<0.05);两组并发症发生率比较差异无统计学意义(P>0.05)。结论:介入溶栓术治疗超早期急性闭塞性脑梗死患者的临床效果显著,治疗时间越短,越有利于降低患者的神经缺损情况及血清BNP、Hcy、PPARγ水平、减少不良发生率,提高患者的生活质量,值得推广应用。Objective:To investigate the influence of interventional thrombolysis on the recovery of neurological function and quality of life in patients with ultra-early acute occlusive cerebral infarction.Method:A total of 62 patients with ultra-early acute occlusive cerebral infarction treated in our hospital from June 2017 to October 2018 were selected as the research subjects.Patients treated within 3 h after onset of disease were taken as the observation group,and patients treated more than 3 h after onset of disease were taken as the control group,with 31 cases in each group.The both groups were treated with interventional thrombolysis.The neurological deficit score,quality of life score,and serum B-type natriuretic peptide(BNP),homocysteine(Hcy),peroxidisome proliferationactivated receptorγ(PPARγ)levels and incidence of complications were compared between the two groups.Result:At 1,7,30 d after treatment,the neurological deficit scores of the observation group were lower than those of the control group(P<0.05).At 3 d after treatment,the mental health,self-evaluation,social function and daily life scores of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05);after 3 d treatment,the serum BNP,Hcy,PPARγlevels of the both groups were significantly lower than those before treatment,the serum BNP,Hcy,PPARγlevels of the observation group were lower than those of the control group(P<0.05).There was no significant difference in incidence of complications(P>0.05).Conclusion:The clinical effect of interventional thrombolysis in the treatment of ultra early acute occlusive cerebral infarction is significant.The shorter the treatment time,the more conducive to reduce the nerve defect and serum BNP,Hcy,PPARγlevels,reduce the incidence of complications,improve the quality of life of patients,which is worthy of promotion and application.

关 键 词：介入溶栓术 超早期急性闭塞性脑梗死 神经功能 生活质量 B型钠尿肽 同型半胱氨酸 过氧化物酶体增殖激活受体Γ 并发症 

分 类 号：R743.3[医药卫生—神经病学与精神病学]