同型半胱氨酸及胆红素对老年患者颅内动脉瘤介入治疗后脑血管痉挛的影响  

Effects of homocysteine and bilirubin on cerebral vasospasm after interventional therapy in elderly patients with intracranial aneurysms

作　　者：刘成业 周奋 何安邦 李钢 Liu Cheng-ye;Zhou Fen;He An-bang;Li Gang(Sanya Central Hospital,Sanya 572000,China)

机构地区：[1]海南省三亚中心医院神经外科,三亚572000

出　　处：《湖南师范大学学报（医学版）》2021年第3期49-52,共4页Journal of Hunan Normal University(Medical Sciences)

基　　金：海南省卫生厅科研课题(琼卫2010-64)。

摘　　要：目的:探讨同型半胱氨酸及胆红素对老年患者颅内动脉瘤介入治疗后脑血管痉挛的影响,为临床诊治提供理论依据。方法:回顾性分析2018年12月~2019年12月我院收治的96例颅内动脉瘤患者的临床资料,根据患者术后是否发生脑血管痉挛分为观察组和对照组,各48例,两组患者均采取颅内动脉瘤介入治疗。观察两组患者的同型半胱氨酸及胆红素水平,比较两组患者不同同型半胱氨酸及胆红素水平变化。结果:观察组患者的同型半胱氨酸水平为[(36.49±8.51)umol/L],明显高于对照组的[(17.35±8.50)umol/L],观察组患者的胆红素水平为[(7.92±4.17)umol/L],明显低于对照组的[(13.67±4.18)umol/L],差异有统计学意义。观察组患者的同型半胱氨酸水平<20umol/L占比32.65%,明显低于对照组的67.35%;观察组患者的同型半胱氨酸水平在60~80umol/L占比88.89%,>80umol/L占比87.50%,明显高于对照组的11.11%、12.50%,差异有统计学意义;两组患者的同型半胱氨酸水平在20~39umol/L、40~59umol/L时比较,差异无统计学意义。观察组患者的胆红素水平≤12.5umol/L占比18.42%、12.6~20umol/L占比34.21%,明显低于对照组的81.58%、65.79%;观察组患者的胆红素水平>35umol/L占比83.33%,明显高于对照组的16.67%,差异有统计学意义;两组患者的胆红素水平在21~35umol/L时比较,差异无统计学意义。结论:老年患者接受颅内动脉瘤介入治疗后,其同型半胱氨酸及胆红素水平越高,发生脑血管痉挛的几率越大,临床应加强对患者以上指标的检测,以提高患者的治疗效果。Objective To investigate the effects of homocysteine and bilirubin on cerebral vasospasm after interventional treatment of elderly patients with intracranial aneurysms,and to provide theoretical basis for clinical diagnosis and treatment.Methods Clinical data of 96 cases patients with intracranial aneurysm admitted to our hospital from December 2018 to December 2019 were retrospectively analyzed,according to whether the patients had cerebral vasospasm after operation,they were divided into observation group and control group,48 cases each,patients in both groups were treated with intracranial aneurysm..Observed the homocysteine and bilirubin levels in the two groups of patients,changes in different homocysteine and bilirubin levels were compared between the two groups of patients.Results The homocysteine level in the observation group patients was[(36.49±8.51)umol/L],which was significantly higher than the control group’s[(17.35±8.50)umol/L],the bilirubin level in the observation group was[(7.92±4.17)umol/L],which was significantly lower than the control group’s[(13.67±4.18)umol/L],the difference was statistically significant.The homocysteine level in the observation group patients was<20umol/L,accounting for 32.65%,which was significantly lower than the control groups 67.35%;The homocysteine levels in the observation group patients were 60~80umol/L,accounting for 88.89%,and>80umol/L,accounting for 87.50%,which were significantly higher than the 11.11%and 12.50%in the control group,the difference was statistically significant;Compared of homocysteine levels between the two groups of patients at 20~39umol/L,40~59umol/L,the difference was not statistically significant.Patients in the observation group had bilirubin levels≤12.5umol/L accounting for 18.42%and 12.6~20umol/L accounting for 34.21%,which were significantly lower than the control groups 81.58%and 65.79%;The bilirubin level in the observation group patients was>35umol/L,accounting for 83.33%,which was significantly higher than the 16.67%in the co

关 键 词：颅内动脉瘤 老年 同型半胱氨酸 胆红素 脑血管痉挛 

分 类 号：R743[医药卫生—神经病学与精神病学]