解毒散结扶正法辅助化疗对老年晚期膀胱癌患者机体免疫状态和肿瘤转移侵袭的影响  

Effect of Adjuvant Chemotherapy with Detoxification,Sanjie and Righting of Traditional Chinese Medicine on Immune Status and Tumor Metastasis and Invasion of Elderly Patients with Advanced Bladder Cancer

作　　者：胡嘉芮 何晓华[1] 王永霞 刘戴维 樊捷婷 李占林[1] Hu Jia-rui;He Xiao-hua;Wang Yong-xia;Liu Dai-wei;Fan Jie-ting;Li Zhan-lin(Department of Traditional Chinese Medicine,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075061,China)

机构地区：[1]河北北方学院附属第一医院,张家口075061

出　　处：《湖南师范大学学报（医学版）》2021年第3期73-77,共5页Journal of Hunan Normal University(Medical Sciences)

基　　金：张家口市科学技术研究与发展计划项目(NO.1911021D-10)。

摘　　要：目的:探究解毒散结扶正法辅助化疗对老年晚期膀胱癌患者机体免疫状态和肿瘤转移侵袭的影响。方法:选取2018年3月~2020年3月期间河北北方学院附属第一医院住院的老年晚期膀胱癌患者132例,采用随机数字表法分为对照组、治疗组,各66例。对照组仅给予化疗,在此基础上,治疗组加用解毒散结扶正法。比较两组临床疗效及不良反应发生情况,并检测两组免疫功能、肿瘤相关因子、缺氧诱导因子-1α(HIF-1α)、肿瘤坏死因子-β1(TNF-β1)及基质金属蛋白酶-2(MMP-2)]以及肿瘤转移侵袭基因表达量[Ⅳ型胶原蛋白基因α1(COL4A1)、钙粘附蛋E(E-cad-herin)、p21活化激酶6(PAK6)、肿瘤坏死因子受体相关蛋白1(TRAP1)的mRNA]的差异。结果:治疗后两组CD4^(+)、CD4^(+)/CD8^(+)均出现显著升高,且治疗组相较于对照组更高;两组CD8^(+)均出现显著降低,且治疗组相较于对照组更低;治疗后两组COL4A1、PAK6、TRAP1 mRNA表达量均出现显著降低,且治疗组相较于对照组更低;两组E-cad-herin mRNA表达量均出现显著升高,且治疗组相较于对照组更高;治疗后两组COL4A1、PAK6、TRAP1 mRNA表达量均出现显著降低,且治疗组相较于对照组更低;两组E-cad-herin mRNA表达量均出现显著升高,且治疗组相较于对照组更高。同时,治疗组临床疗效明显高于对照组,且不良反应明显低于对照组。结论:解毒散结扶正法辅助化疗治疗老年晚期膀胱癌可有效抑制病灶中恶性分子的转移侵袭,调节肿瘤血管的生长,且对其免疫功能的的改善效果较好,疗效显著且安全可靠。Objective To explore the effect of adjuvant chemotherapy with Detoxification,Sanjie and Righting of Traditional Chinese Medicine on the immune status and tumor metastasis and invasion of elderly patients with advanced bladder cancer.Methods From March 2018 to March 2020,132 elderly patients with advanced bladder cancer who were hospitalized in the Department of Traditional Chinese Medicine of the First Affiliated Hospital of Hebei North University were selected and divided into a control group and a treatment group with 66 cases each by a random number table.The control group was given chemotherapy only,and on this basis,the treatment group was given Detoxification,Sanjie and Righting of Traditional Chinese Medicine.The clinical efficacy and adverse reactions were compared between the two groups,and the immune function(CD4^(+),CD8^(+),CD4^(+)/CD8^(+)),tumor-related factors and tumor metastasis invasion gene expression.Results After treatment,CD4^(+)and CD4^(+)/CD8^(+)were significantly increased in the two groups,and the treatment group was higher than the control group;CD8+decreased significantly in the two groups,and the treatment group was lower than the control group;after treatment,the expression of COL4A1,PAK6,TRAP1 mRNA in both groups decreased significantly.And the treatment group was lower than the control group;the two groups of E-cad-herin mRNA expression The amount of COL4A1,PAK6,TRAP1 mRNA in the two groups was significantly decreased after treatment,and the treatment group was higher than the control group;The treatment group was lower than the control group;the two groups of E-cad-herin mRNA expression There was a significant increase,and the treatment group was higher than the control group.At the same time,the clinical efficacy of the treatment group was significantly higher than that of the control group,and the adverse reactions were significantly lower than the control group.Conclusion The adjuvant chemotherapy with Detoxification,Sanjie and Righting of Traditional Chinese Medicine in the trea

关 键 词：解毒散结扶正法 化疗 老年晚期膀胱癌 免疫状态 肿瘤转移侵袭 

分 类 号：R737.14[医药卫生—肿瘤]