左乙拉西坦联合奥卡西平治疗女性部分性癫痫发作的疗效及对骨代谢、骨密度的影响  

Efficacy of levetiracetam combined with oxcarbazepine in the treatment of partial seizures in women and its effect on bone metabolism and bone mineral density

作　　者：张海峰 李光[2] 刘永霞 Zhang Hai-feng;Li Guang;Liu Yong-xia(Clinical Laboratory,Ping An Hospital,Xicheng District,Beijing 100035,China;Department of Pathology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Clinical Laboratory,Xiexicheng Road Hospital,Beijing 100044,China)

机构地区：[1]北京市西城区平安医院检验科,北京100035 [2]首都医科大学附属北京天坛医院病理科,北京100070 [3]北京市西城区展览路医院检验科,北京100044

出　　处：《湖南师范大学学报（医学版）》2021年第2期16-19,共4页Journal of Hunan Normal University(Medical Sciences)

基　　金：国家科技支撑计划课题项目(NO.2013BAI17B00,2013BAI17B04);北京市西城区2014年度科技新星项目。

摘　　要：目的:探讨应用左乙拉西坦联合奥卡西平治疗女性部分性癫痫发作的临床效果及其对患者骨代谢和骨密度的影响,为临床选择治疗方案提供参考。方法:选取2017年10月~2019年3月于本院就诊的86例女性部分性癫痫发作的患者为研究对象,根据随机数表法,分成观察组(44例)与对照组(42例)。对照组给予奥卡西平单药治疗,观察组给予左乙拉西坦联合奥卡西平治疗,治疗24周。比较两组患者的疗效、骨代谢、骨密度及不良反应。结果:观察组患者的总有效率(95.45%)明显高于对照组患者(78.57%),差异有统计学意义。两组患者治疗前血钙、血磷水平与治疗后相比,差异无统计学意义,两组患者治疗前碱性磷酸酶水平均明显低于治疗后,差异有统计学意义。两组患者治疗前、治疗后血钙、血磷及碱性磷酸酶水平比较,差异无统计学意义。两组患者治疗后股骨颈、Ward三角区、腰2~4椎骨、骨密度较治疗前均明显下降,差异有统计学意义;两组患者治疗前股骨大转子骨密度与治疗后相比,差异无统计学意义。两组患者治疗前、治疗后股骨颈、Ward三角区、腰2~4椎骨、股骨大转子骨密度相比,差异均无统计学意义。观察组患者的头晕、嗜睡、皮疹、过敏总不良反应发生率与对照组患者比较,差异无统计学意义。结论:左乙拉西坦和奥卡西平联合治疗女性部分性癫痫发作能够显著改善治疗效果,对患者骨代谢和骨密度影响小,且不良反应少,值得在临床推广应用。Objective To investigate the efficacy of levetiracetam combined with oxcarbazepine in the treatment of partial seizures in women and its effects on bone metabolism and bone mineral density,and to provide a reference for clinical treatment options.Methods 86 female patients with partial seizures from October 2017 to March 2019 were enrolled in the study.They were divided into observation group(44 cases)and control group(42 cases)according to the random number table method.The control group was treated with oxcarbazepine alone,and the observation group was treated with levetiracetam combined with oxcarbazepine for 24 weeks.The efficacy,bone metabolism,bone density,quality of life,and adverse reactions were compared between the two groups.Results The total effective rate(95.45%)was significantly higher in the observation group than in the control group(78.57%),and the difference was statistically significant.There were no significant difference in serum calcium and phosphorus levels between the two groups before and after treatment.The alkaline phosphatase levels in the two groups before treatment was significantly lower than those after treatment,and the differences were statistically significant.There were no significant difference in blood calcium,serum phosphorus and alkaline phosphatase between the two groups before and after treatment.The bone mineral density of the 2~4 vertebrae,Ward triangle and femoral neck of the two groups were significantly lower than that before treatment,and the differences were statistically significant.There were no significant difference in bone mineral density between the two groups before treatment and after treatment.There were no significant difference in bone mineral density of 2~4 vertebrae,ward triangle,femoral neck and femur trochanter between the two groups before and after treatment.The total incidence of adverse reactions(15.91%)in the observation group compared with the control group(9.52%)was not statistically significant.Conclusion The combination of levetiracetam and

关 键 词：部分性癫痫发作 女性 左乙拉西坦 奥卡西平 疗效 骨代谢 骨密度 

分 类 号：R742.1[医药卫生—神经病学与精神病学]