术前外周血NLR比值在胃癌根治术后患者预后中的评估作用  

Evaluation of NLR Ratio in preoperative peripheral Blood in Patients with gastric Cancer after radical Gastrectomy

作　　者：卡米力·吐尔逊 来比江·吾斯曼 贾腾飞[1] 张文斌[1] Kamili Turson;Leibjan Osman;JIA Tengfei;ZHANG Wenbin(Department of gastroenterology,First Affiliated Hospital of Xinjiang Medical University,Urumqi Xinjiang 830054,China)

机构地区：[1]新疆医科大学第一附属医院胃肠外科,新疆乌鲁木齐830054

出　　处：《临床研究》2021年第7期1-4,共4页Clinical Research

摘　　要：目的探讨术前外周血中性粒细胞与淋巴细胞比值(NLR)在胃癌根治术后患者预后中的评估作用。方法选择2013年1月至2017年7月在新疆医科大学第一附属医院行R0胃癌根治术的166例胃癌患者为研究对象,全部患者术前行外周血细胞分类计数计算NLR,根据ROC曲线计算出NLR最佳临界点,将患者分为高NLR组(NLR≥1.74)117例,低NLR组(NLR<1.74)49例。比较两组患者临床病理特征和预后。结果随访166例患者,其中低NLR组1年、3年生存率分别为91.84%、75.51%,高NLR组1年、3年生存率分别为90.60%、49.57%,单因素分析中维吾尔族、病理分型低分化组织类型、肿瘤N分期N1、N2、N3、TNM分期Ⅲ期、较高的NLR被确定为与总体生存期(OS)相关的不良预后因素;多因素分析中病理分型低分化组织类型、肿瘤T分期T3分期和NLR为与OS相关的独立预后因素。结论术前NLR比值可作为R0胃癌根治术后患者生存率的独立预后因素,对评估患者预后有重要预测价值。Objective To evaluate the prognostic value of preoperative neutrophil to lymphocyte ratio(NLR)in patients with gastric cancer after radical gastrectomy.Methods From January 2013 to July 2017,166 patients with gastric cancer who underwent R0 radical gastrectomy in First Affiliated Hospital of Xinjiang Medical University were selected as the study subjects.All patients were counted NLR by peripheral blood cell count,the best critical point of NLR was calculated by ROC curve.117 patients with high NLR(NLR≥1.74)and 49 patients with low NLR(NLR<1.74).The Clinical Pathology features and prognosis were compared between the two groups.Results Follow-up of 166 patients,the 1-year and 3-year survival rates were 91.84%and 75.51%in low NLR group,and 90.60%and 49.57%in high NLR group,univariate analysis showed that Uyghur,pathologic type low differentiated tissue type,Tumor N stage N1,N2,N3,TNMⅢ,and higher NLR were associated with overall survival(OS).Pathologic type low differentiated tissue type,T3 stage of tumor T stage and NLR were independent prognostic factors associated with OS in multivariate analysis.Conclusion Preoperative NLR ratio can be used as an independent prognostic factor for the survival rate of R0 patients after radical gastrectomy,it has important predictive value for evaluating the prognosis of patients.

关 键 词：胃癌 NLR 预后 

分 类 号：R73.2[医药卫生—肿瘤]