急性脑梗死患者纤溶亢进相关危险因素分析  

Analysis of related risk factors of hyperfibrinolysis in patients with acute cerebral infarction

作　　者：谭经 余和平[2] 彭晓华[2] 孔渝菡[2] 杨世喜 TAN Jing;YU Heping;PENG Xiaohua;KONG Yuhan;YANG Shixi(Zhanjiang Central Hospital,Guangdong Medical University,Zhanjiang 524045,China;The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]广东医科大学附属湛江中心医院,广东湛江524045 [2]重庆医科大学附属第一医院,重庆400016

出　　处：《中国实用神经疾病杂志》2021年第12期1054-1060,共7页Chinese Journal of Practical Nervous Diseases

基　　金：重庆市卫健委课题(编号:2018jstg007)。

摘　　要：目的探讨急性脑梗死患者纤溶亢进的相关危险因素。方法回顾分析2017-09—2018-10重庆医科大学附属第一医院住院治疗的符合纳入标准的急性脑梗死患者130例,采用Logistic回归方程进行危险因素分析。结果Logistic回归分析显示,高龄、发病时舒张压过低、超敏C反应蛋白升高和无高脂血症是急性脑梗死患者纤溶亢进的危险因素;长期服用他汀类药物可能是纤溶亢进的保护因素;各项血脂水平、糖尿病、性别、抽烟、饮酒等均不是纤溶亢进的预测因素。结论高龄、发病时舒张压过低和超敏C反应蛋白升高的急性脑梗死患者血液更易呈现高凝或纤溶亢进状态。急性脑梗死纤溶亢进不受血脂的影响,但长期服用他汀类药物可能改善患者血液纤溶亢进状态。Objective To explore the risk factors of hyperfibrinolysis in patients with acute cerebral infarction.Methods A retrospective analysis was made on 130 patients with acute cerebral infarction who met the inclusion criteria in our hospital from September 2017 to October 2018.The risk factors were analyzed by logistic regression equation.Results showed that advanced age,low diastolic blood pressure,elevated hypersensitive C-reactive protein and no hyperlipidemia were risk factors of hyperfibrinolysis in patients with acute cerebral infarction,long-term use of statins might be protective factors of hyperfibrinolysis,and various levels of blood lipids,diabetes,sex,smoking and drinking were not predictive factors of hyperfibrinolysis.Conclusion Acute cerebral infarction patients with advanced age,low diastolic blood pressure and elevated hypersensitive C-reactive protein are more likely to show hypercoagulability or hyperfibrinolysis.Hyperfibrinolysis in patients with acute cerebral infarction is not affected by blood lipids,but long-term use of statins may effectively improve blood fibrinolysis in patients with acute cerebral infarction.

关 键 词：急性脑梗死 危险因素 保护因素 纤溶系统 高凝状态 

分 类 号：R743.33[医药卫生—神经病学与精神病学]