三阴性乳腺癌组织中FOXJ1、SATB1的表达变化及临床意义  

Expression of FOXJ1 and SATB1 in triple negative breast cancer and its clinical significance

作　　者：付飞国 王忆丽 雷秋模 FU Feiguo;WANG Yili;LEI Qiumo(Department of Breast Surgery,the Third Hospital of Nanchang,Jiangxi Province,Nanchang 330009,China)

机构地区：[1]南昌市第三医院乳腺外科,江西南昌330009

出　　处：《中国医药导报》2021年第16期38-41,51,共5页China Medical Herald

基　　金：江西省卫生计生委科技计划项目(20171116)。

摘　　要：目的探讨三阴性乳腺癌叉头框蛋白J1(FOXJ1)和核基质结合区结合蛋白质1(SATB1)表达与临床病理参数及预后的关系。方法检测2014年2月—2015年3月南昌市第三医院收治的98例三阴性乳腺癌患者为研究对象,收集癌组织以及癌旁组织备用,分析FOXJ1和SATB1表达及其与临床病理参数的关系,Kaplan-Meier生存曲线分析不同FOXJ1、SATB1表达患者5年总生存率的差异。结果三阴性乳腺癌组织中FOXJ1阳性率低于癌旁组织(P<0.01);SATB1阳性率高于癌旁组织(P<0.01)。三阴性乳腺癌组织中,不同FOXJ1表达与TNM分期及肿瘤分化程度有关(P<0.05或P<0.01);不同SATB1表达与肿瘤浸润深度、TNM分期以及淋巴结是否转移有关(P<0.05或P<0.01)。三阴性乳腺癌中,FOXJ1表达与SATB1表达呈负相关(r=-0.625,P<0.05)。FOXJ1阳性患者5年总生存率高于阴性患者,而SATB1阳性患者的5年总生存率低于SATB1阴性患者(均P<0.01)。结论三阴性乳腺癌组织中FOXJ1低表达,SATB1高表达,共同参与三阴性乳腺癌的发生发展过程,并与三阴性乳腺癌患者的预后相关,检测FOXJ1、SATB1表达有助于患者的预后评估。Objective To investigate the relationship between the expression of forkhead box J1(FOXJ1)and special AT rich sequence binding protein 1(SATB1)and clinicopathological parameters and prognosis of triple negative breast cancer.Methods A total of 98 patients with triple negative breast cancer admitted to the Third Hospital of Nanchang from February 2014 to March 2015 were selected as study subjects.Cancer tissues and paracancerous tissues were collected for use.The expression of FOXJ1 and SATB1 and their relationship with clinicopathological parameters were analyzed.The difference of five-year overall survival rate among patients with different FOXJ1,SATB1 expression were analyzed by Kaplan-Meier survival curve.Results The positive rate of FOXJ1 in triple negative breast cancer tissues was lower than that in paracancerous tissues(P<0.01);and the positive rate of SATB1 was higher than that of paracancerous tissues(P<0.01).In triple negative breast cancer tissues,different FOXJ1 expression was correlated with TNM stage and tumor differentiation degree(P<0.05 or P<0.01);different SATB1 expression was associated with the depth of tumor invasion,TNM stage,and whether lymph node metastasis(P<0.05 or P<0.01).The expression of FOXJ1 was negatively correlated with the expression of SATB1 in triple negative breast cancer(r=-0.625,P<0.05).The five-year overall survival rate of FOXJ1 positive patients was higher than that of negative patients,while the five-year overall survival rate of SATB1 positive patients was lower than that of negative patients(all P<0.01).Conclusion The low expression of FOXJ1 and high expression of SATB1 in triple-negative breast cancer tissues are both involved in the occurrence and development of triple negative breast cancer,and are correlated with the prognosis of patients with triple negative breast cancer.Detection the expression of FOXJ1 and SATB1 are helpful for the prognosis evaluation of patients.

关 键 词：三阴性乳腺癌 叉头框蛋白J1 核基质结合区结合蛋白质1 预后 

分 类 号：R737.9[医药卫生—肿瘤]