HS-AFP、CEA和T淋巴细胞亚群水平与PHC病人接受RFA治疗效果及生存期的关系  

Relationship between HS-AFP,CEA and T lymphocyte subsets and the efficacy and survival of patients with PHC receiving RFA

作　　者：刘鹏年[1] 谢飞[1] 王洪斌[1] Liu Peng-nian;Xie Fei;Wang Hong-bin(Department of Liboralory,Yizhou Cancer Hospital,Hebei Province The Liboraton of the Hospital of Meizhou City,Haoding 072750,China)

机构地区：[1]河北一洲肿瘤医院检验科,涿州市医院检验科,保定072750

出　　处：《湖南师范大学学报（医学版）》2021年第1期42-46,共5页Journal of Hunan Normal University(Medical Sciences)

基　　金：保定市社发类项目(NO.1941ZF094)。

摘　　要：目的:探讨HS-AFP、CEA和T淋巴细胞亚群水平与PHC病人接受RFA治疗效果及生存期的关系。方法:选取我院2013年1年1月~2016年6月间收治的125例接受RFA治疗的PHC患者作为研究对象,采用实体瘤疗效评价标准对患者治疗近期临床疗效进行评估,采用酶联免疫吸附法检测患者血中HS-AFP、CEA水平,并采用流式细胞术法检测患者血中CD^(4+)T细胞、CD^(8+)T细胞水平。结果:治疗前后PHC患者血中HS-AFP、CEA及CD^(8+)T细胞水平均明显降低,CD^(4+)T细胞水平均明显升高,且差异存统计学意义;治疗前后患者治疗后短期临床有效组患者血中HS-AFP、CEA及CD^(8+)T细胞水平均明显低于无效组,且CD^(4+)T细胞水平均明显高于治疗无效组,且差异存统计学意义;治疗前后HS-AFP、CEA、CD^(8+)T细胞低表达状态患者生成率均明显优于高表达组,CD^(4+)T细胞高表达状态患者生成率均明显优于低表达组;治疗前后HS-AFP、CEA、CD^(8+)T及CD^(4+)T水平均是影响患者治疗临床疗效和生存情况的独立性影响因素。结论:检测HS-AFP、CEA及T淋巴细胞亚群水平对PHC病人接受RFA治疗的疗效评估及生存期分析具有重要意义。Objective To explore the relationship between HS-AFP,CEA and T lymphocyte subsets and the efficacy and survival of patients with PHC receiving RFA.Methods A total of 125 patients with PHC who underwent RFA treatment from January 1 to June 2016 in our hospital were enrolled in the study.The short-term clinical efficacy of the patients was evaluated by solid tumor efficacy evaluation criteria,using enzyme-linked immunosorbent assay.The levels of HS-AFP and CEA in the blood of patients were detected,and the levels of CD^(4+) T cells and CD^(8+) T cells in blood were detected by flow cytometry.Results The levels of HS-AFP,CEA and CD^(8+) T cells in PHC patients were significantly decreased before and after treatment,and the levels of CD^(4+) T cells were significantly increased,and the difference was statistically significant.The levels of HS-AFP,CEA and CD^(8+) T cells in the effective group were significantly lower than those in the ineffective group,and the level of CD^(4+) T cells was significantly higher than that in the treatment-ineffective group,and the difference was statistically significant.The incidence of HS-AFP,CEA and CD^(8+) T cells in the low expression state was significantly better than that in the high expression group.The incidence of CD^(4+) T cells in the high expression state was significantly better than that in the low expression group.HS-AFP and CEA before and after treatment.The CD^(8+) T and CD^(4+) T levels were independent factors influencing the clinical efficacy and survival of patients.Conclusions The detection of HS-AFP,CEA and T lymphocyte subsets is of great significance for the evaluation of the efficacy and survival analysis of PHC patients receiving RFA.

关 键 词：原发性肝癌 射频消融术 肝癌特异性甲胎蛋白 癌胚抗原 T淋巴细胞亚群 

分 类 号：R735.7[医药卫生—肿瘤]