人参联合电针足三里对帕金森非运动症状Cys-C、S-100B、NSE的影响研究  

The Effects of ginseng combined with electroacupuncture Zusanli on non-motor symptoms and Cys-C,S-100B and NSE in Parkinson

作　　者：朱佩敏[1] Zhu Pei-min(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《湖南师范大学学报（医学版）》2021年第1期81-84,共4页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:探究人参联合电针足三里对帕金森患者非运动症状及其Cys-C、S-100B和NSE水平的影响。方法:按入院先后顺序将2017年3月~2019年1月在我院治疗的106例帕金森患者分为观察组(56例)和对照组(50例)。对照组患者口服美多芭进行治疗,观察组患者在上述基础上煎服人参,并采用电针刺激足三里穴。治疗后,对两组患者的临床疗效、非运动症状、情绪及认知功能以等指标变化进行观察、比较。结果:观察组、对照组的总有效率分别为78.57%、56.00%,差异比较有统计学意义。两组患者在治疗12周后的NMSS、NMSQuest评分均明显低于治疗前,观察组患者在治疗12周后的NMSS、NMSQuest评分明显低于对照组。两组在治疗12周后的HAMA、HAMD和MMSE评分均显著低于治疗前,观察组在治疗12周后的HAMA、HAMD和MMSE评分均明显低于对照组。两组患者在治疗12周后的血清Csy-C、S-100B以及NSE水平均明显低于治疗前,观察组在治疗12周后的血清Csy-C、S-100B以及NSE水平均明显低于对照组。观察组的不良反应发生率为1.79%,对照组为4.00%,差异比较无统计学意义。结论:人参联合电针足三里可显著降低帕金森病患者的血清Cys-C、S-100B、NSE水平,显著改善其非运动症状,其效果优于单纯医药治疗,值得在临床上积极推广。Objective To research the effects of ginseng combined with electroacupuncture Zusanli on non-motor symptoms and Cys-C,S-100B and NSE in Parkinson’s patients.Method 106 cases patients with Parkinson’s disease who admitted to our hospital from March 2017 to January 2019 were selected as the study objects.They were divided into observation group (56 cases) and control group (50 cases) according to the order of admission.The patients in the control group were treated with Madopa.The patients in the observation group were decocted ginseng on the basis of the above,and used electro-acupuncture to stimulate Zusanli point.Result The total effective rates of the observation group and the control group were 78.57% and 56.00% respectively,the difference was statistically significant.The scores of NMS and NMSQuest in the two groups after 12 weeks treatment were significantly lower than those before treatment,the scores of NMS and NMSQuest in the observation group after 12 weeks treatment were significantly lower than those in the control group during the same time.The scores of HAMA,HAMD and MMSE of two groups after 12 weeks treatment were significantly lower than those before treatment,the scores of HAMA,HAMD and MMSE in the observation group after 12 weeks treatment were significantly lower than those of the control group at the same time.The serum Csy-C,S-100B and NSE levels in the two groups after 12 weeks treatment were significantly lower than those before treatment,the levels of serum Csy-C,S-100B and NSE in the observation group were significantly lower than control group after 12 weeks treatment,with statistical significance.The incidence of adverse reactions was 1.79% in the observation group and 4.00% in the control group,there was no significant difference between the two groups.Conclusion Ginseng combined with electro-acupuncture Zusanli can significantly reduce the serum levels of Cys-C,S-100B and NSE in patients with Parkinson’s disease,and can significantly improve their non-motor symptoms at the same t

关 键 词：帕金森 非运动症状 人参 电针刺激 足三里穴 血清胱抑素C 中枢神经特异蛋白 神经元特异性烯醇化酶 

分 类 号：R742.5[医药卫生—神经病学与精神病学]