癌胚抗原相关细胞黏附分子6和增殖细胞核抗原在涎腺黏液表皮样癌中的表达及临床意义  

Expression and clinical significance of CEACAM 6 and Ki-67 in mucoepidermoid carcinoma of salivary glands

作　　者：马赛[1] 安峰[1] 李立恒[1] 林媛媛[2] 汪佳[1] MA Sai;AN Feng;LI Liheng;LIN Yuanyuan;WANG Jia(Department of Stomatology,The First Affiliated Hospital of Hebei North College,ZhangJiakou,Hebei 075000,China;Department of Pathology,The First Affiliated Hospital of Hebei North College,ZhangJiakou,Hebei 075000,China)

机构地区：[1]河北北方学院附属第一医院口腔科,河北张家口075000 [2]河北北方学院附属第一医院病理科,河北张家口075000

出　　处：《安徽医药》2021年第7期1369-1372,共4页Anhui Medical and Pharmaceutical Journal

基　　金：河北省重点研发计划自筹项目(172777144);张家口市2018年度科学技术研究与发展计划资助项目(1811032D-7);河北北方学院2018年度校级科研一般项目(YB2018022)。

摘　　要：目的研究癌胚抗原相关细胞黏附分子6(CEACAM 6)与增殖细胞核抗原(Ki-67)在不同病理特征的涎腺黏液表皮样癌(MEC)中的表达情况及临床意义。方法应用免疫组织化学SP法检测2005年6月至2014年10月河北北方学院附属第一医院病理科留存的50例不同临床病理特征的涎腺MEC组织、30例正常涎腺组织与30例多形性腺瘤(SPA)中CEACAM 6与Ki-67的表达情况。结果CEACAM 6、Ki-67在涎腺MEC组中阳性表达率分别为62.00%(31/50)、56.00%(28/50),在涎腺SPA组中分别为33.33%(10/30)、30.00%(9/30),在正常涎腺组中分别为20.00%(6/30)、13.33%(4/30),涎腺MEC组显著高于对照组(P<0.0167);在不同病理特征的涎腺MEC组间比较中,CEACAM 6、Ki-67在病理分级组、TNM分期组、有无淋巴结转移组中的表达阳性率差异有统计学意义(P<0.05),病理分级Ⅲ组、TNM分期Ⅲ+Ⅳ组、有淋巴结转移组的阳性表达均分别高于病理分级Ⅰ+Ⅱ级组、TNM分期Ⅰ+Ⅱ组、无淋巴结转移组,而在不同性别、年龄、部位组中CEACAM 6、Ki-67表达阳性率差异无统计学意义(P>0.05);在涎腺MEC中CEACAM 6与Ki-67的表达呈正相关(r_(s)=0.551,P<0.001)。结论在涎腺MEC组织中CEACAM 6可能是通过调控Ki-67的表达来促进肿瘤组织的增殖。检测CEACAM 6和Ki-67可以为涎腺MEC的诊断、治疗提供参考。Objective(CEACAM 6)and proliferating cell nuclear antigen Ki-67 in mucoepidermoid carcinoma of salivary glands.Methods The expression of CEACAM 6 and Ki-67 in 50 cases of MEC,30 cases of SPA and 30 cases of normal tissues in the Department of Pathology of The First Affiliated Hospital of Hebei North College from June 2005 to October 2014 were detected by immunohistochemical method.The relationship between their expression and different clinical pathological features in MEC of salivary glands were analyzed.Results The positive expression rates of CEACAM 6 and Ki-67 were 62.00%(31/50)and 56.00%(28/50)in MEC tissues,33.33%(10/30)and30.00%(9/30)in SPA tissues,20.00%(6/30)and 13.33%(4/30)in normal tissues.The positive rates of CEACAM 6,Ki-67 were higher in MEC tissues than those in SPA tissues and normal tissues(P<0.0167).In the comparison of different pathological features of salivary gland MEC groups,the positive expressions of CEACAM 6 and Ki-67 were significant difference in the groups of differentpathological grade level,different TNM stage and patients with or without lymph node metastasis,the difference was statistically significant(P<0.05),pathological grade levelⅢpatients,TNM stageⅢ+Ⅳ,and patients with lymph node metastasis were higher than those in pathological grade levelⅠ+Ⅱpatients,TNM stageⅠ+Ⅱpatients and patients without lymph node metastasis.There was no significant difference beween the positive expressions of CEACAM 6 and Ki-67 in the groups of different genders,ages and tumor sites(P>0.05).There was a positive correlation beween the positive expressions of CEACAM 6 and Ki-67 in MEC tissues(r_(s)=0.551,P<0.001).Conclusion CEACAM 6 and Ki-67 could provide reference for the diagnosis and treatment of MEC of salivary glands.

关 键 词：涎腺肿瘤 癌胚抗原类 KI-67抗原 增殖 

分 类 号：R739.87[医药卫生—肿瘤]