IL-1基因多态性与MS患者遗传易感性关系的meta分析  

Relationship between interleukin-1 gene polymorphisms and genetic susceptibility in patients with multiple sclerosis:a meta analysis

作　　者：张明亮 刘方洲[3] 李伟霞[1] 张辉[1] 王晓艳[1] 张书琦 王炎 贾文汇 牛璐 唐进法[1,4] ZHANG Mingliang;LIU Fangzhou;LI Weixia;ZHANG Hui;WANG Xiaoyan;ZHANG Shuqi;WANG Yan;JIA Wenhui;NIU Lu;TANG Jinfa(Henan Provincial Engineering Laboratory for Clinical Evaluation Technology of Chinese Medicine,First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan 450000,China;College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610000,China;Henan Provincial Chinese Medicine Research Institute,Zhengzhou,Henan 450000,China;College of Pharmacy,Henan University of Traditional Chinese Medicine,Zhengzhou,Henan 450000,China)

机构地区：[1]河南中医药大学第一附属医院中药临床评价技术河南省工程实验室,郑州450000 [2]成都中医药大学药学院,成都610000 [3]河南省中医药研究院,郑州450000 [4]河南中医药大学药学院,郑州450000

出　　处：《重庆医学》2021年第12期2105-2110,2115,共7页Chongqing medicine

基　　金：国家自然科学基金青年基金项目(82004021);2019年度河南省中医药科学研究专项项目(2019ZY2144);2020年度河南省科技攻关课题项目(202102310185)。

摘　　要：目的探讨白细胞介素1(IL-1)基因多态性与多发性硬化症(MS)患者遗传易感性的关系。方法通过Pubmed、Elseiver、Ovid、中国知网(CNKI)和万方数据库,检索有关IL-1基因多态性与MS病例对照研究文献,并对其结果进行统计分析。结果共纳入23篇符合标准的文献。纳入研究的各基因的等位基因与基因型均未见明显发表偏倚。在LL vs.22模型中,IL-1ra(VNTR)基因位点中LL为MS的保护性基因型(OR=0.819,95%CI:0.683~0.982,P=0.031),而IL-1β(+3953)、IL-1α(-889)、IL-1β(-511)未见有显著关联。亚组分析中,发现IL-1α(-889)C等位基因与IL-1β(+3953)C等位基因分别是亚洲MS患者的风险性、保护性因素(OR=1.453,95%CI:1.204~1.755,P=0.000;OR=0.591,95%CI:0.459~0.762,P=0.000),而IL-1α(-889)C等位基因则是位于“>50°N”MS患者的保护性因素(OR=0.815,95%CI:0.695~0.957,P=0.012)。结论IL-1基因多态性与MS患者的遗传易感性有相关性,且与种族和地域有一定关系。Objective To investigate the relationship between interleukin-1(IL-1)gene polymorphism and genetic susceptibility in the patients with multiple sclerosis(MS).Methods The case-control studies on IL-1 gene polymorphism and MS patients were retrieved through Pubmed,Elseiver,Ovid,CNKI and Wanfang databases,and the results were statistically analyzed.Results A total of 23 case-control studies conforming to the standard were included.No significant publication bias was observed in alleles and genotypes of the included genes.In the LL vs.22 model,LL was found to be the protective genotype of MS in IL-1ra(VNTR)gene loci(OR=0.819,95%CI:0.683-0.982,P=0.031),while no significantly association was not seen in IL-1β(+3953),IL-1α(-889)and IL-1β(-511).In subgroup analysis,it was found that IL-1α(-889)C allele and IL-1β(+3953)C allele were the risk or protective factors for the Asian MS patients(OR=1.453,95%CI:1.204-1.755,P=0.000;OR=0.591,95%CI:0.459-0.762,P=0.000)respectively,while IL-1α(-889)C allele was the protective factor in the patients in">50°N"(OR=0.815,95%CI:0.695-0.957,P=0.012).Conclusion The IL-1 gene polymorphism is correlated with the genetic susceptibility of MS patients,moreover has a certain relation with race and region.

关 键 词：多发性硬化症 白细胞介素-1 基因多态性 META分析 

分 类 号：R744.51[医药卫生—神经病学与精神病学]