人趋化素样因子超家族成员CMTM4在疾病中对细胞功能的调控  

Regulation of human chemokine-like superfamily member CMTM4 on cellular function in diseases

作　　者：王雅心(综述) 赵秀娟[1] 朱凤雪(审校)[1] WANG Yaxin;ZHAO Xiujuan;ZHU Fengxue(Trauma Center,Peking University People′s Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院创伤救治中心,100044

出　　处：《重庆医学》2021年第12期2116-2120,共5页Chongqing medicine

基　　金：国家自然科学基金项目(81971808)。

摘　　要：CMTM家族是含有MARVEL穿膜结构域的蛋白质家族,其功能介于经典趋化因子和TM4SF之间,对肿瘤性疾病、免疫、造血、生殖系统疾病的发生、发展均具有一定影响。CMTM4是CMTM家族中最保守的膜分子,广泛表达于人类多种正常组织,研究发现其在某些肿瘤中表达下调,加快肿瘤细胞增殖、侵袭,是潜在的抑癌基因;对程序性死亡受体1(PD-L1)具有保护作用,间接调节机体免疫细胞功能,参与免疫逃逸;还对细胞连接和男性生殖系统疾病具有调控作用。本文对有关CMTM4分子的已有研究做一综述,介绍CMTM4在疾病背景下对细胞功能的调控作用,以期为日后对CMTM4的研究和临床转化方向提供借鉴。The CMTM family is a protein family containing MARVEL transmembrane structural domains,whose functions are between classic chemokines and TM4SF,and have a certain effect on the occurrence and development of neoplastic disease and immune,hematopoietic,reproductive system diseases.CMTM4 is the most conservative membrane molecule in the family.It is widely expressed in a variety of normal human tissues.The studies have found that its expression is down-regulated in some tumors,which accelerates the tumor cell proliferation and invasion,and is a potential tumor suppressor gene.CMTM4 has the protective effect on PD-L1,indirectly regulates the body′s immune cell function and participates in immune escape.It also has a regulatory effect on cell connections and male reproductive system diseases.This article summarizes the existing researches on the CMTM4 molecule,and introduces the regulation effect of CMTM4 on cell function in the context of disease,hoping to provide a reference for the future research and clinical transformation direction of CMTM4.

关 键 词：趋化因子类 细胞周期 肿瘤 CMTM4 CKLF蛋白 程序性死亡受体1 黏附连接 

分 类 号：R73.370[医药卫生—肿瘤]