术前NLR和PLR与肝门胆管癌根治术后临床病理特征及T分期的关系  

Relationship between preoperative NLR and PLR and clinicopathological characteristics and T stage after laparoscopic radical resection of hilar cholangiocarcinoma

作　　者：李传涛 周迟 王兆映 鲁正[1] 崔培元[1] LI Chuan-tao;ZHOU-Chi;WANG Zhao-ying;LU Zheng;CUI Pei-yuan(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院肝胆外科,安徽蚌埠233004

出　　处：《中华全科医学》2021年第7期1095-1098,共4页Chinese Journal of General Practice

基　　金：安徽省自然科学基金(2008085MH256)。

摘　　要：目的收集近10年本科室肝门胆管癌(HC)患者的病例资料。研究术前中性粒细胞与淋巴细胞比(NLR)和血小板与淋巴细胞比(PLR)与HC临床病理特征及T分期的关系。方法回顾性分析2010年1月—2019年12月在蚌埠医学院第一附属医院肝胆外科术后病理为HC患者的资料,共有100例患者被纳入。通过受试者工作特征(ROC)曲线确定NLR和PLR的最佳截止值,统计分析术前NLR和PLR与HC病理特征及T分期的关系,以及对T分期的预测价值。结果ROC曲线确定最佳截止值,高NLR组(NLR>4.12,56例)和低NLR组(NLR≤4.12,44例);高PLR组(>184.56,48例)和低PLR组(≤184.56,52例)。单因素分析表明,术前NLR与肿瘤位置和T分期有相关性(均P<0.05),与性别、年龄、分化程度、肿瘤大小等无关(均P>0.05);术前PLR与T分期、肿瘤大小和淋巴结转移有相关性(均P<0.05),与性别、年龄、分化程度、肿瘤位置等无关(均P>0.05)。多因素分析结果表明,术前NLR与T分期(OR=2.999,P=0.026)和肿瘤位置(OR=0.346,P=0.032)有关;术前PLR与T分期(OR=3.635,P=0.007)和肿瘤大小(OR=1.728,P=0.031)有关,与淋巴结转移转移无关(P>0.05)。术前NLR和PLR的ROC曲线面积为0.811和0.794,对T分期有预测价值。结论术前NLR和PLR是一种简单、实用的检测指标,可用于术前对HC病理特征的评估,对T分期有预测价值。Objective To study the relationship between preoperative neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)with the clinicopathological characteristics and T staging of hilar cholangiocarcinoma(HC).Methods The data of patients with HC were analyzed retrospectively.The receiver operating characteristic(ROC)curve was used to determine the best cut-off values of NLR and PLR.Statistical analysis of preoperative NLR and PLR and HC pathological characteristics and the relationship between T staging and the predictive value of T staging.Results The ROC curve was used to determine the best cut-off value:high-NLR group(NLR>4.12,56 cases),low-NLR group(NLR≤4.12,44 cases),high-PLR group(>184.56,48 cases)and low-PLR group(≤184.56,52 cases).Univariate analysis showed that preoperative NLR was correlated with tumour location and T stage(all P<0.05)and had no correlation with gender,age,degree of differentiation and tumour size(all P>0.05).Preoperative PLR was correlated with T stage,tumour size and lymph node metastasis(all P<0.05)and had no correlation with gender,age,degree of differentiation and tumour location(all P>0.05).Multivariate analysis showed that preoperative NLR was associated with T staging(OR=2.999,P=0.026)and tumour location(OR=0.346,P=0.032).Preoperative PLR was related to T stage(OR=3.635,P=0.007)and tumour size(OR=1.728,P=0.031),but not to lymph node metastasis(P>0.05).The ROC curve areas of NLR and PLR before surgery were 0.811 and 0.794,respectively,which have predictive value for T staging.Conclusion Preoperative NLR and PLR are simple and practical detection indicators that can be used to evaluate the pathological characteristics of HC before surgery and have predictive value for T staging.

关 键 词：肝门胆管癌 中性粒细胞与淋巴细胞比 血小板与淋巴细胞比 

分 类 号：R735.8[医药卫生—肿瘤]