帕金森病患者身体质量指数及其与相关症状的关系  

Analysis of body mass index and related symptoms in patients with Parkinson disease

作　　者：汪传歌 周志华 刘爱群[1] 黄叶青[1] 余青云[1] 彭忠兴[1] 洪铭范[1] WANG Chuange;ZHOU Zhihua;LIU Aiqun;HUANG Yeqing;YU Qingyun;PENG Zhongxing;HONG Mingfan(Department of Neurology,the First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou,510080,China)

机构地区：[1]广东药科大学附属第一医院神经内科,广州510080

出　　处：《中国神经精神疾病杂志》2021年第3期129-133,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省基础与应用基础研究基金(编号:2019A1515011314)。

摘　　要：目的研究帕金森病(Parkinson disease,PD)患者身体质量指数(body mass index,BMI)变化及其与PD运动症状和非运动症状之间的关系。方法纳入83例PD患者和同期65名健康体检者作为对照。患者均进行统一的PD评分量表(unified Parkinson disease rating scale,UPDRS)第三部分UPDRS-Ⅲ评定、改良Hoehn-Yahr(H-Y)分级评定,汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)和抑郁量表(Hamilton depression scale,HAMD)、简易智力状态健康量表(mini mental state health scale,MMSE)和蒙特利尔认识评定量表(Montreal cognitive assessment scale,MoCA)及便秘评分系统(constipation scoring system,CCS)评分和卧立位血压测定。根据BMI结果将PD组分为低BMI PD组和不伴低BMI PD组。结果PD组与对照组比较,PD组BMI[(21.4±2.3)kg/m^(2) vs.(23.7±1.2)kg/m^(2)]、MMSE(24.7±1.8 vs.25.9±1.7)、MoCA(23.6±2.4 vs.25.9±1.3)评分均更低(P<0.01),收缩压下降[(13.0±3.0)mmHg vs.(8.3±2.3)mmHg]及舒张压下降[(7.1±1.7)mmHg vs.(5.2±1.4)mmHg]更多、CCS评分(15.4±2.8 vs.12.2±2.9)、HAMA(8.3±3.0 vs.6.6±2.0)及HAMD(11.1±4.1 vs.6.9±1.8)评分更高(P<0.01)。低BMI组较不伴低BMI组MMSE(22.9±2.1 vs.25.1±1.6)、MoCA(21.2±1.8 vs.24.0±2.0)评分均更低(P<0.01),收缩压下降(16.5±2.0 mmHg vs.12.3±2.7 mmHg)及舒张压下降(8.2±2.0 mmHg vs.6.9±1.6 mmHg)更多,CCS评分(18.3±3.2 vs.14.8±2.4)、HAMD(18.4±2.6 vs.9.8±2.7)及HAMA(13.8±2.2 vs.7.3±1.7)评分更高(P<0.01)。结论PD患者BMI降低,伴低BMI的PD患者运动及非运动症状更严重,临床需要重视对PD患者的BMI动态监测。Objective In order to study the changes of body mass index(BMI)and its relationship with motor and non-motor symptoms in patients with Parkinson's disease(PD).Methods Eighty-three PD patients and 65 healthy controls were recruited.All patients were assessed using the three part of Unified Parkinson disease rating scale(UPDRS-Ⅲ),modified Hoehn Yahr(H-Y)grading,Hamilton Anxiety Scale(HAMA)and Depression Scale(HAMD),mini mental state health scale(MMSE),Montreal Cognitive Assessment Scale(MoCA),constipation scoring system(CCS)and supine blood pressure were measured.According to the results of BMI,PD patients were divided into PD with low BMI group and PD without low BMI group.Results Compared with healthy control group and PD group,BMI(21.4±2.3 vs.23.7±1.2),MMSE(24.7±1.8 vs.25.9±1.7),MoCA(23.6±2.4 vs.25.9±1.3)scores of PD group were lower(all P<0.01),reduced systolic(13.0±3.0 vs.8.3±2.3)and diastolic(7.1±1.7 mmHg vs.5.2±1.4 mmHg)blood pressure,CCS scores(15.4±2.8 vs.12.2±2.9),HAMA(8.3±3.0 vs.6.6±2.0)and HAMD(11.1±4.1 vs.6.9±1.8)scores were higher(all P<0.01).The scores of MMSE(22.9±2.1 vs.25.1±1.6)and MOCA(21.2±1.8 vs.24.0±2.0)were lower in PD with low BMI group than those without low BMI group(all P<0.01),and the reduced systolic(16.5±2.0 mmHg vs.12.3±2.7 mmHg)and diastolic(8.2±2.0 mmHg vs.6.9±1.6 mmHg)blood pressure,CCS score(18.3±3.2 vs.14.8±2.4),HAMD(18.4±2.6 vs.9.8±2.7)and HAMA(13.8±2.2 vs.7.3±1.7)score were higher in PD with low BMI group than those without low BMI group(all P<0.01).Conclusion BMI is lower in PD patients than in healthy control.Motor and non-motor symptoms are more severe in PD patients with low BMI,which suggests the importance of the dynamic monitoring of BMI in PD patients.

关 键 词：帕金森病 身体质量指数 运动症状 非运动症状 

分 类 号：R742.5[医药卫生—神经病学与精神病学]