双酚A类似物的雄性生殖毒性研究进展  

Research progress in male reproductive toxicity of bisphenol A analogues

作　　者：李红梅[1,2] 熊忆茗 徐海明 李圆圆 李金波[1,2] 秦占芬 LI Hong-mei;XIONG Yi-ming;XU Hai-ming;LI Yuan-yuan;LI Jin-bo;QIN Zhan-fen(State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China;College of Resources and Environmeal University of Chinese Academy of Sciences,Beijing 100049;Department of Occupational and Environmental Hygiene,School of Public Health and Management,Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京100085 [2]中国科学院大学资源与环境学院,北京100049 [3]宁夏医科大学公共卫生与管理学院职业卫生与环境卫生学系,宁夏银川750004

出　　处：《中国环境科学》2021年第6期2939-2945,共7页China Environmental Science

基　　金：国家重点研发计划(2018YFA0901103);国家自然科学基金资助项目(21876196)。

摘　　要：聚焦BPA类似物对雄性动物的生殖毒性研究,分析双酚S、双酚F、双酚AF、双酚B和双酚E对哺乳类实验动物睾丸及组织结构、附睾重量及组织学结构、激素水平、精子参数等常规指标的影响,考察关于鱼类和两栖类动物的研究.研究发现,不管暴露剂量高低、暴露方式的差异或是动物种属的不同,所有BPA类似物的暴露都显示阳性结果,这与BPA雄性生殖毒性尚有争议的事实形成对比,暗示这些BPA类似物具有比BPA更明显的雄性生殖毒性.总体来看,目前的BPA类似物雄性生殖毒性的数据只局限在有限的几个实验室,且实验的质量控制难以评价.因此,BPA类似物的雄性生殖毒性的数据还需要更多实验室的验证,并且过程中需要严格控制动物实验的质量,以获得更加可靠且可重复的结果.This paper examined studies on bisphenol analogues and male reproductive toxicity with the focus on analyzing the data involving toxic effects of bisphenol analogues on the testis and organization structure,weight and histological structure of epididymis,hormone levels and sperm parameters in mammals,and investigating several essays about fish and amphibian animal research.All BPA analogues had reproductive hazards in these animals regardless of dose,mode of exposure,or species of animals,which suggested that these BPA analogues had more significant male reproductive toxicity than that of BPA on which researches were still debating.However,the majority of data points on the male reproductive toxicity of BPA analogues was limited from a few laboratories and quality control was also hard to discern.Therefore,to obtain more reliable and repeatable results,the findings on male reproductive toxicity of BPA analogues need to be verified by more laboratories,and the quality of animal experiments should be strictly controlled.

关 键 词：双酚A 类似物 雄性 生殖毒性 质量控制 

分 类 号：X171.5[环境科学与工程—环境科学] R114[医药卫生—卫生毒理学]