ABCC11基因多态性对非小细胞肺癌患者S-1辅助化疗预后的价值分析  

Effects of ABCC11 gene polymorphism on the prognosis of patients with non small cell lung cancer treated by S1 adjuvant chemotherapy

作　　者：邢国柱 沈会华[1] 李悟[1] XING Guozhu;SHEN Huihua;LI Wu(Department of Cardio-thoracic Surgery,General Hospital of Xinjiang Military District,Xinjiang,Urumqi 830000,China)

机构地区：[1]新疆军区总医院心胸外科,乌鲁木齐市830000

出　　处：《河北医药》2021年第12期1797-1800,共4页Hebei Medical Journal

摘　　要：目的探讨S-1辅助化疗后ABCC11基因多态性对ⅠB-ⅢA期NSCLC患者预后的影响。方法选择60例NSCLC患者作为研究对象,手术切除肺叶后对患者进行S-1化疗,分析患者临床病例特征,包括组织学特征、肿瘤大小、ABCC11基因中的单核苷酸多态性以及5-Fu通路相关酶等,并且解析其与5年生存率之间的关系。结果NSCLC患者的总生存期(OS)和无复发生存期(RFS)分别为73.3%和69.5%,鳞状细胞癌患者的OS比肺腺癌患者短(P=0.032);肿瘤≥34 mm的患者相较于肿瘤≤33 mm的患者OS也短(P=0.013)。RFS单因素分析发现,PS≥1(P=0.031)、淋巴管浸润(P=0.005)、血管浸润(P=0.003)以及A/A型SNP538(P=0.012)均表现出较短的生存时间。对40例疗效达到或超过70%的患者5-年存活率进行分析,发现A/A型SNP538(P=0.003)、TS免疫组化结果为阴性(P=0.018)以及PS≥1(P=0.026)均为RFS较差的显著预测因子。多因素Cox回归分析发现只有A/A型SNP538表现出显著的危险比(P=0.002)。结论本研究的5年生存率分析表明ABCC11基因中的A/A型SNP538是术后患者接受S-1辅助治疗是否会复发的重要预测因子。由于A/A型SNP538对应于干型耳垢,因此基于S-1的辅助化疗可能因耳垢类型的不同而产生个性化差异。Objective To investigate the effects of ABCC11 gene polymorphism on the prognosis of patients with non small cell lung cancer(NSCLC)treated by S1 adjuvant chemotherapy.Methods A total of 60 patients with NSCLC were enrolled in the study,who were treated by S1 chemotherapy after lobular resection.The clinical features,including histological characteristics,tumor size,single nucleotide polymorphism in ABCC11 gene as well as 5-Fu pathway related enzymes were observed and analyzed,moreover,and the correlation between clinical features and 5 year survival rate was analyzed.Results The overall survival duration(OS)and relapse free survival(RFS)of patients were 73.3%and 69.5%,respectively.The OS of patients with squamous cell carcinoma was significantly shorter than that of patients with lung adenocarcinoma(P<0.05).Moreover the OS of patients with tumor size≥34mm was significantly shorter than that of patients with tumor size≤33mm(P<0.05).Univariate analysis of RFS showed that PS≥1 lymphatic vessel invasion,blood vessel invasion,and the A/A type of SNP538 were significantly associated with the shorter survival duration of patients(P<0.05).The analysis for the 5-year survival rate of 40 patients with curative effect over 70%showed that A/A type SNP538,TS negative immunohistochemical results and PS≥1 were the significant predictors of poor RFS.Multivariate Cox regression analysis showed that only A/A type of SNP538 presented a significant risk ratio(P<0.01).Conclusion The 5 year survival rate analysis shows that A/A type of SNP538 in ABCC11 gene is an important predictor of relapse in patients with NSCLC who receive S1 adjuvant therapy.Since the A/A type of SNP538 corresponds to dry earwax,S1 adjuvant chemotherapy may have individuation differences due to the different types of earwax.

关 键 词：非小细胞肺癌 S-1 ABCC11基因多态性 

分 类 号：R734.2[医药卫生—肿瘤]