Frizzled-7靶向治疗的抗肿瘤研究进展  

Progress in anti-tumor research of Frizzled-7-targeting therapy

作　　者：赵慧杰 王进 解伟 ZHAO Hui-Jie;WANG Jin;XIE Wei(School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;School of Pharmacy,Shanghai University of Medicine and Health Sciences,Shanghai 201318,China;Shanghai Key Laboratory of Molecular Imaging,Shanghai University of Medicine and Health Sciences,Shanghai 201318,China;Graduate School,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]上海健康医学院药学院,上海201318 [3]上海市分子影像学重点实验室,上海201318 [4]上海理工大学研究生院,上海200093

出　　处：《生命科学》2021年第4期460-465,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81703401);上海市教育委员会和上海市教育发展基金会“晨光计划”(18-CG72);上海市分子影像学重点实验室(18DZ2260400)。

摘　　要：Wnt信号通路在物种进化过程中高度保守,并在肿瘤的发生发展中发挥至关重要的作用。Frizzled(Fzd)蛋白是Wnt受体家族,该家族中有10个成员蛋白,Frizzled-7(Fzd7)为成员之一。研究表明,Fzd7在多种恶性肿瘤中被显著上调,通过激活Wnt通路调控细胞增殖、肿瘤侵袭与迁移,并影响肿瘤细胞干性。Fzd7的上调与肿瘤化疗耐受以及患者的低生存率显著相关,靶向Fzd7在体内外均表现出了良好的抗肿瘤效果。因此,Fzd7是恶性肿瘤潜在的治疗靶点。该文对Fzd7在癌症中的表达与功能以及Fzd7的靶向治疗作一综述。Wnt signaling pathway is highly conserved throughout evolution and plays a critical role in cancer development and progression.Wnt receptor family contains 10 members,and Frizzled-7(Fzd7)is one of key receptors.It has been demonstrated that Fzd7 is up-regulated in multiple malignancies,and involved in the proliferation,invasion,migration of tumor cells via activating Wnt signaling pathway.In addition,Fzd7 plays a key role in stem cell biology.The aberrant up-regulation of Fzd7 is significantly associated with the chemotherapy tolerance and inferior survival rates of tumor patients.Furthermore,targeted therapy of Fzd7 exhibits potent anticancer activity in vitro and in vivo.In conclusion,Fzd7 may serve as a potential therapeutic target in cancer treatment.In this article,we summarized the expression and function of Fzd7 and reviewed Fzd7-targeting therapy.

关 键 词：Frizzled-7 WNT信号通路 Β-CATENIN 靶向治疗 肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]