TIGAR在脑缺血中作用的研究进展  

Research progress of the role of TIGAR in cerebral ischemia

作　　者：赵航 陈静[1] 杨丹丹 ZHAO Hang;CHEN Jing;YANG Dan-Dan(Medical College,China Three Gorges University,Yichang 443002,China;The Second Renmin Hospital,China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学医学院,宜昌443002 [2]三峡大学第二人民医院,宜昌443002

出　　处：《生命科学》2021年第4期512-517,共6页Chinese Bulletin of Life Sciences

基　　金：天然产物研究与利用湖北省重点实验室开放基金(NPRD-2018001);湖北省卫健委联合基金重点项目(WJ2019H526);国家自然科学基金面上项目(82073824)。

摘　　要：TP53诱导的糖酵解和凋亡调节剂(TP53-induced glycolysis and apoptosis regulator, TIGAR)是参与p53引起的糖酵解和凋亡的重要因素,其与代谢稳态关系密切。TIGAR可通过减轻氧化应激、自噬、凋亡、炎症以及线粒体功能障碍来减轻缺血性脑损伤,发挥神经保护作用。现就TIGAR的基本信息、调节因素以及其在脑缺血中的作用进行综述,为脑缺血的预防和治疗提供理论依据。TP53-induced glycolysis and apoptosis regulator(TIGAR) is an important factor involved in glycolysis and apoptosis caused by p53, and it is also closely related to metabolic homeostasis. TIGAR can reduce ischemic brain injury and exert neuroprotective effects by reducing oxidative stress, autophagy, apoptosis, inflammation, and mitochondrial dysfunction. This article summarizes basic information and regulatory factors of TIGAR, and its role in cerebral ischemia to provide a theoretical basis for the prevention and treatment of cerebral ischemia.

关 键 词：TIGAR 脑缺血 缺血再灌注 代谢 

分 类 号：R743.3[医药卫生—神经病学与精神病学]