非小细胞肺癌脉管癌栓的相关性分析及对手术后预后的影响  

Correlation analysis of vascular tumor thrombus in non-small cell lung cancer and its influence on postoperative prognosis

作　　者：郭根军 刘尚国[2] 张俊杰 张侠杰 GUO Genjun;LIU Shangguo;ZHANG Junjie;ZHANG Xiajie(Department of Thoracic Surgery,Hebi Jingli Hospital,Henan Hebi 458030,China;Department of Thoracic Surgery,the First Affiliated Hospital of Xinxiang Medical College,Henan Xinxiang 453100,China;Department of Pain,Hebi City Hospital of Traditional Chinese Medicine,Henan Hebi 458030,China.)

机构地区：[1]鹤壁京立医院胸外科,河南鹤壁458030 [2]新乡医学院第一附属医院胸外科,河南新乡453100 [3]鹤壁市中医院疼痛科,河南鹤壁458030

出　　处：《现代肿瘤医学》2021年第13期2265-2268,共4页Journal of Modern Oncology

摘　　要：目的:探究脉管癌栓对非小细胞肺癌手术后预后的影响。方法:回顾性分析我院232例非小细胞肺癌患者临床资料和病理资料,CD34标记血管癌栓,D2-40标记淋巴管癌栓,Logistic回归分析影响非小细胞肺癌患者手术后预后的独立危险因素,比较脉管癌栓组患者和无脉管癌栓组患者生存率差异,比较淋巴管癌栓组和血管癌栓组患者生存率差异。结果:不同病理分型、临床分期、肿瘤大小、淋巴结转移、手术方式、化疗情况和脉管癌栓均会影响非小细胞肺癌患者手术后预后(P<0.05);临床分期、肿瘤大小、淋巴结转移和脉管癌栓均为影响非小细胞肺癌患者手术后预后的独立危险因素(P<0.01);脉管癌栓组生存期显著低于无脉管癌栓组(P<0.01);血管癌栓组生存率显著低于淋巴管癌栓组(P<0.05);血管癌栓组VEGF高表达比率显著高于淋巴管癌栓组(P<0.01)。结论:脉管癌栓是非小细胞肺癌手术后预后独立危险因素,其中血管癌栓是主要危险因素。Objective:To investigate the effect of cancerous vascular tumor thrombus on the prognosis of non-small cell lung cancer after surgery.Methods:The clinical data and pathological data of 232 patients with non-small cell lung cancer in our hospital were retrospective analysed.CD34 labeled blood vessel invasion,and D2-40 labeled lymphatic vessel invasion.Logistic regression analysed independent risk factors affecting the prognosis of non-small cell lung cancer patients after surgery.The survival rate of patients with vascular tumor thrombosis group and non-vascular tumor thrombosis group was compared,and the survival rate of patients with lymphatic tumor thrombosis group and vascular tumor thrombus group was compared.Results:Different pathological types,clinical stage,tumor size,lymph node metastasis,surgical methods,chemotherapy and vascular tumor thrombosis all affected the prognosis of patients with non-small cell lung cancer(P<0.05).Clinical stage,tumor size,lymph node metastasis and vascular tumor thrombus were independent risk factors for postoperative prognosis in patients with non-small cell lung cancer(P<0.01).The survival time of the vascular tumor thrombus group was significantly lower than that of the non-vascular tumor thrombus group(P<0.01).The survival rate of blood vessel invasion was significantly lower than that of lymphatic vessel invasion group(P<0.05).The VEGF high expression rate of blood vessel invasion group was significantly higher than that of lymphatic vessel invasion group(P<0.01).Conclusion:Vascular tumor thrombus is an independent risk factor for the prognosis of non-small cell lung cancer(NSCLC)after operation,and blood vessel invasion is the main risk factor.

关 键 词：非小细胞肺癌 脉管癌栓 手术预后 血管癌栓 VEGF 

分 类 号：R734.2[医药卫生—肿瘤]