蜂蜜对成人恶性血液病化疗性口腔黏膜炎的预防效果研究  

The effects of honey on oral mucositis prevention in adults with malignant hematological disease undergoing chemotherapy:a randomized controlled trial

作　　者：方颖[1] 黄丽华[1] 孙彩虹[2] 杜锋蔚[2] 罗旭霞[2] 谢洪琼[2] FANG Ying;HUANG Li-hua;SUN Cai-hong;DU Feng-wei;LUO Xu-xia;XIE Hong-qiong

机构地区：[1]浙江大学医学院附属第一医院护理部,杭州市310003 [2]浙江大学医学院附属第一医院血液病科,杭州市310003

出　　处：《中华护理教育》2021年第6期544-547,共4页Chinese Journal of Nursing Education

基　　金：浙江省教育厅一般科研项目(自然科学类)(Y201839301)。

摘　　要：目的探讨蜂蜜对血液病患者化疗引起的口腔黏膜炎的预防效果。方法选择2018年7月-2019年3月在3所三级综合医院接受化疗的白血病或淋巴瘤患者98例,随机分为试验组和对照组,每组各49例。对照组给予常规口腔护理和碱性漱口水漱口,试验组在对照组干预的基础上给予蜂蜜涂抹于口腔黏膜表面。比较两组口腔黏膜炎的发生率、发生时间和严重程度。结果试验组口腔黏膜炎的发生率低于对照组(χ^(2)=5.288,P<0.05);两组开始发生口腔黏膜炎的时间差异无统计学意义(t=0.386,P=0.705);两组发生口腔黏膜炎的严重程度差异无统计学意义(P>0.05)。结论蜂蜜可降低化疗导致的口腔黏膜炎的发生率,对化疗导致的口腔黏膜炎有预防效果。Objective To examine the effects of honey on oral mucositis prevention in adults with malignant hematological disease undergoing chemotherapy.Methods In this prospective randomized clinical trial,98 patients with leukemia or lymphoma undergoing chemotherapy in three tertiary general hospitals from July 2018 to March 2019,were randomly allocated into two groups:the experimental group(n=49)and the control group(n=49).Patients in the control group were given routine oral care and alkaline mouthwash,while patients in the experimental group were given honey on the surface of the oral mucosa in addition to the routine care.The incidence,time,and severity of oral mucositis between the two groups were compared.Results The incidence of oral mucositis in the experimental group was significantly lower than that in the control group(χ^(2)=5.288,P<0.05).There was no significant differences in the time of oral mucositis occurrence between the two groups(t=0.386,P=0.705).There was also no significant differences in oral mucositis severity in two groups(P>0.05).Conclusion Honey can reduce the incidence of chemotherapy-induced oral mucositis,and has a preventive effect on chemotherapy-induced oral mucositis.

关 键 词：口腔黏膜炎 蜂蜜 化学疗法 辅助 血液肿瘤 

分 类 号：R473.73[医药卫生—护理学]