结合基因分析予难治性癫痫患儿精准护理的临床效果研究  

Clinical effect of precise nursing combined with gene therapy in children with intractable epilepsy

作　　者：黄文慧[1] 韦琴[1] 韩蕴丽[1] 石靖[1] 梁秀安[1] 宁莉[1] Hang Wenhui;Wei Qin;Han Yunli;Shi Jing;Liang Xiuan;Ning Li(Department of Pediatrics,The First Affiliat-ed Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院儿科,南宁530021

出　　处：《广西医科大学学报》2021年第6期1234-1238,共5页Journal of Guangxi Medical University

基　　金：广西医疗卫生适宜技术开发与推广应用项目(No.S2017033);广西卫计委计划自筹经费课题资助项目(No.I20170600)。

摘　　要：目的:探讨结合基因检测结果指导难治性癫痫患儿精准护理的临床效果。方法:选取2017年1月至2018年3月在广西医科大学第一附属医院儿科就诊的难治性癫痫患儿及其家长60例,按随机数字表法分为观察组和对照组,每组30例。对照组给予常规护理,观察组采用基因评估予精准护理(包括指导癫痫安全防范、评估发作类型、避免诱因、合并症的早期康复训练、遗传咨询),比较干预前及干预后1个、3个、6个月两组患儿的发作次数和疗效,并采用焦虑自评量表(SAS)和抑郁自评量表(SDS)比较两组家长干预前及干预后6个月的焦虑、抑郁情绪。结果:干预后3个、6个月,观察组患儿发作次数显著少于对照组(P<0.05)。两组患儿干预后1个月总有效率比较,差异无统计学意义(P>0.05);观察组干预后3个、6个月总有效率明显高于对照组(P<0.05)。护理干预前,两组患儿家长SAS和SDS评分比较,差异均无统计学意义(均P>0.05);干预后6个月,观察组患儿家长SAS和SDS评分均显著低于对照组(均P<0.01)。结论:结合基因检测结果予难治性癫痫患儿精准护理,能减少癫痫发作次数,提高疗效,并改善患儿家长的焦虑、抑郁情绪。Objective: To explore the clinical effect of precision nursing for children with intractable epilepsy guided by genetic test results. Methods:A total of 60 children with refractory epilepsy treated in our hospital from January 2017 to March 2018 were selected, and randomly divided into an observation group and a control group, with 30 cases in each group. The control group received routine nursing care, and the observation group received personalized nursing intervention by gene evaluation, includingepilepsy safety precautions guidance, epileptic seizure type assessment, attack inducement intervention, early rehabilitation training for complications and genetic counseling. The frequency of seizures and curative effect were compared between the two groups before and after 1, 3, 6 months of intervention. The self-rating anxiety scale(SAS) and self-rating depression scale(SDS) were used to compare the anxiety and depression mood of the parents before and 6 months after intervention. Results: At 3 and 6 months after intervention, the frequency of seizures in the observation group was significantly less than that in the control group(P<0.05) There was no significant difference in the total effective rate after one month of intervention between the two groups(P<0.05). The total effective rate of observation group at3 months and 6 months after intervention was significantly higher than that of control group(P<0.05) Before nursing intervention, there was no significant difference in SAS and SDS scores between the parents of the two groups(P<0.05). At 6 months after intervention, SAS and SDS scores of parents in the observation group were significantly lower than those in the control group(P<0.01). Conclusion: Precise nursing care combined with gene detection results can reduce seizures, improve the curative effect, and attenuate the anxiety and depression of the parents of children with intractable epilepsy.

关 键 词：基因 难治性癫痫 精准护理 

分 类 号：R742.1[医药卫生—神经病学与精神病学]