氯吡格雷联合酒石酸美托洛尔治疗急性心肌梗死的临床效果  

Clinical Effect of Clopidogrel Combined With Metoprolol Tartrate in the Treatment of Acute Myocardial Infarction

作　　者：侯思捷[1] 罗智敏[2] 何洁英[3] HOU Sijie;LUO Zhimin;HE Jieying(Department of Pharmacy,Foshan Hospital of Traditional Chinese Medicine,Foshan Guangdong 528000,China;Department of Cardioloy,Foshan Hospital of Traditional Chinese Medicine,Foshan Guangdong 528000,China;Department of Pharmacy,Foshan First People’s Hospital,Foshan Guangdong 528000,China)

机构地区：[1]佛山市中医院药剂科,广东佛山528000 [2]佛山市中医院心血管科,广东佛山528000 [3]佛山市第一人民医院药学部,广东佛山528000

出　　处：《中国卫生标准管理》2021年第11期77-80,共4页China Health Standard Management

摘　　要：目的探讨氯吡格雷联合酒石酸美托洛尔治疗对急性心肌梗死患者临床效果及HR、TC、LVDD的影响。方法选取2019年11月—2020年11月于医院就诊的急性心肌梗死(acute myocardial infarction,AMI)患者66例,随机分为两组。对照组应用氯吡格雷,研究组应用酒石酸美托洛尔+氯吡格雷。观察比对两组治疗前后的炎性因子水平变化情况,心功能相关指标变化情况,TC、HR以及不良反应发生情况。结果研究组治疗后IL-10水平(2.65±0.61)pg/m L高于对照组(1.74±0.35)pg/mL,MIF水平(12.02±3.19)ng/L低于对照组(15.41±4.04)ng/L(P<0.05);研究组LVSD(32.71±3.44)mm、IVST(9.03±1.18)mm、LVDD水平(47.55±2.17)mm均低于对照组(39.02±4.14)mm、(11.36±1.04)mm、(54.11±4.25)mm,LVEF(59.48±3.09)%高于对照组(52.13±4.57)%(P<0.05);研究组不良反应发生率(6.1%)、TC(5.11±0.21)mmol/L、HR(80.11±50.12)次/min均低于对照组27.3%、(6.88±1.24)mmol/L、(95.78±7.12)次/min(P<0.05)。结论AMI应用酒石酸美托洛尔+氯吡格雷治疗效果较好,可以降低炎性因子水平和不良反应的发生率,同时还能改善心功能。Objective To investigate the clinical effect of clopidogrel combined with metoprolol tartrate on patients with myocardial infarction and the influence of HR,TC and LVDD.Methods 66 patients with acute myocardial infarction(AMI)in our hospital from November 2019 to November 2020 were randomly divided into two groups.Clopidogrel was used in the control group and metoprolol tartrate+clopidogrel was used in the study group.The changes of inflammatory factors,cardiac function related indicators,TC,HR and adverse reactions were observed and compared between the two groups before and after treatment.Results After treatment,the IL-10 level of the study group(2.65±0.61)pg/mL was higher than that of the control group(1.74±0.35)pg/mL,and the MIF level(12.02±3.19)ng/L was lower than that of the control group(15.41±4.04)ng/L(P<0.05).LVSD(32.71±3.44)mm,IVST(9.03±1.18)mm and LVDD(47.55±2.17)mm in the study group were all lower than those in the control group(39.02±4.14)mm,(11.36±1.04)mm and(54.11±4.25)mm,and LVEF(59.48±3.09)%was higher than those in the control group(52.13±4.57)%(P<0.05).The incidence of adverse reactions(6.1%),TC(5.11±0.21)mmol/L and HR(80.11±50.12)times/min in the study group were all lower than those in the control group(27.3%),(6.88±1.24)mmol/L and(95.78±7.12)times/min(P<0.05).Conclusion Metoprolol tartrate+clopidogrel has a good therapeutic effect on AMI,which can reduce inflammatory factors and the incidence of adverse reactions,and improve cardiac function.

关 键 词：氯吡格雷 酒石酸美托洛尔 急性心肌梗死 临床效果 HR TC LVDD 

分 类 号：R541[医药卫生—心血管疾病]