盆腔放疗后功能不全性骨折的研究进展  

Research progress in insufficient fracture after pelvic radiotherapy

作　　者：李雯[1] 潘继元 李毅[1] 任宏涛[1] 王亚利[1] Li Wen;Pan Jiyuan;Li Yi;Ren Hongtao;Wang Yali(Department Radiation Oncology of the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]西安交通大学第二附属医院肿瘤放疗科,710004

出　　处：《中华放射医学与防护杂志》2021年第6期469-474,共6页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金(81141097)。

摘　　要：盆腔放疗是大部分盆腔肿瘤的一种治疗方式,盆腔功能不全性骨折(PIF)是盆腔放疗的远期并发症。本篇综述对骨盆功能不全性骨折的研究进展进行了总结和讨论,其发病机制主要与成骨细胞被抑制有关,危险因素有老年、绝经后状态、缺乏激素替代治疗、高分娩次数、吸烟史、低体质量指数(BMI)、并发类风湿性关节炎、并发糖尿病、高剂量率腔内近距离治疗(HDR-ICBT)以及高放疗剂量等,目前尚无有效药物用于预防和治疗。PIF一旦延迟诊断或误诊可引起严重的后果,因此需要更进一步的研究来指导临床工作。Pelvic radiotherapy is a way for treatment of most pelvic tumors,of which the pelvic insufficiency fracture(PIF)is a long-term complication.In this review,research progress of pelvic insufficiency fracture is summarized and discussed.The pathogenesis of PIF is mainly about inhibition of osteoblasts and the risk factors of PIF include old age,postmenopausal status,absence of hormonal replacement therapy,high number of births,smoking history,low body mass index(BMI),concurrent rheumatoid arthritis,concurrent diabetes mellitus,intracavitary brachytherapy of the high dose rate(HDR-ICBT),high dose of radiotherapy,etc.Effective drugs for prevention or treatment of PIF have not been found yet.Delayed diagnosis and misdiagnosis of PIF can cause serious consequences.As a result,further studies are needed to guide clinical work.

关 键 词：盆腔肿瘤 放射治疗 盆腔功能不全性骨折 

分 类 号：R730.55[医药卫生—肿瘤] R683[医药卫生—临床医学]