左旋肉碱虾青素复合营养素治疗特发性少精子症和弱精子症的多中心临床观察  

L-carnitine-astaxanthin compound nutrients for the treatment of idiopathic oligospermia and asthenozoospermia:A multicenter clinical observation

作　　者：李焕[1] 邓浩 刘晃 钟安 翁治委[3] 黄昌平[4] 骆强翔[4] 赵善超[5] 朱永通[6] 杜鹏[7] 莫小东 罗道升[8] 谢斯盛[8] 谢强[8] 张欣宗 Huan;DENG Hao;LIU Huang;ZHONG An;WENG Zhi-wei;HUANG Chang-ping;LUO Qiang-xiang;ZHAO Shan-chao;ZHU Yong-tong;DU Peng;MO Xiao-dong;LUO Dao-sheng;XIE Si-sheng;XIE Qiang;ZHANG Xin-zong(Center of Reproductive Medicine,Foshan Maternal and Child Health Hospital,Southern Medical University,Foshan,Guangdong 528000,China;Department of Andrology,Family Planning Special Hospital of Guangdong Province,Guangzhou,Guangdong 510600,China;Center of Reproductive Medicine,The First Affiliated Hospital of Guangdong University of Chinese Medicine,Guangzhou,Guangdong 510405,China;Center of Reproductive Medicine,Jiangmen Central Hospital,Jiangmen,Guangdong 529000,China;Department of Urology,Nanfang Hospital of Southern Medical University,Guangzhou,Guangdong 510000,China;Center of Reproductive Medicine,Nanfang Hospital of Southern Medical University,Guangzhou,Guangdong 510000,China;Department of Reproductive Health and Infertility,Guangdong Maternal and Child Health Center,Guangzhou,Guangdong 510000,China;Department of Reproductive Medicine,Dongguan People's Hospital,Dong-guan,Guangdong 523000,China)

机构地区：[1]佛山市妇幼保健院生殖中心,广东佛山528000 [2]广东省计划生育专科医院男科,广东广州510600 [3]广州中医药大学第一附属医院生殖中心,广东广州510405 [4]江门市中心医院生殖中心,广东江门529000 [5]南方医科大学附属南方医院,泌尿外科,广东广州510000 [6]南方医科大学附属南方医院生殖中心,广东广州510000 [7]广东省妇幼保健院生殖健康与不孕症科,广东广州510000 [8]东莞市人民医院生殖医学科,广东东莞523000

出　　处：《中华男科学杂志》2021年第4期334-339,共6页National Journal of Andrology

摘　　要：目的:研究左旋肉碱虾青素复合营养素(梦兰康)治疗特发性少精子症及弱精子症的临床疗效。方法:293例患者纳入本研究,其中少精子症73例,弱精子症220例。患者口服左旋肉碱虾青素复合营养素1袋,每日2次,连续服用3个月,分别于治疗前及治疗后第1、2、3个月进行精液分析检测及精子DNA碎片指数(DFI)检测。结果:服用左旋肉碱虾青素复合营养素1个月后及2个月后与用药前相比,少精子症患者精子浓度[(16.74±11.15)×10^(6)/ml、(17.56±9.92)×10^(6)/ml vs(10.96±6.09)×10^(6)/ml]、精子总数[(52.98±32.07)×10^(6)、(57.67±36.98)×10^(6)vs(29.78±17.48)×10^(6)]、前向运动精子百分率[(45.3±14.03)%、(46.42±10.69)%vs(39.8±11.66)%]均显著提高(P<0.05);弱精子症患者前向运动精子百分率较用药前显著提高[(25.46±13.86)%、(27.33±12.88)%vs(19.23±8.32)%,P<0.05]。服药3个月后与用药前相比,少精子症患者精液量[(3.63±1.39)ml vs(3.07±1.47)ml]、精子浓度[(20.56±14.7)×10^(6)/ml vs(10.96±6.09)×10^(6)/ml]、精子总数[(66.35±55.91)×10^(6)vs(29.78±17.48)×10^(6)]、前向运动精子百分率[(49.24±13.45)%vs(39.8±11.66)%]、正常形态精子百分率[(2.59±0.93)%vs(1.71±1.07)%]均显著提高(P<0.05);弱精子症患者精液量[(3.85±1.59)ml vs(3.27±1.42)ml]、前向运动精子百分率[(29.11±13.58)%vs(19.23±8.32)%]、正常形态精子百分率[(2.57±1.15)%vs(2.01±1.14)%]均显著提高(P<0.05)。服药1个月后少精子症及弱精子症患者精子DFI较服药前均无明显改善,连续服药2个月及3个月后,少精子症患者精子DFI较用药前显著下降[(18.66±10.83)%、(16.48±11.46)%vs(25.87±13.76)%,P<0.05],弱精子症患者精子DFI较用药前显著下降[(19.35±11.54)%、(15.32±10.89)%vs(26.40±12.28)%,P<0.05]。结论:左旋肉碱虾青素复合营养素(梦兰康)可以显著改善少精子症及弱精子症患者精液质量。Objective:To investigate the clinical effects of the L-carnitine-astaxanthin compound nutrients Menglankang(MLK)on idiopathic oligospermia(OS)and asthenospermia(AS).Methods:This study included 73 cases of OS and 220 cases of AS treated with MLK once a bag,bid,for 3 successive months.Before and at 1,2 and 3 months after treatment,we obtained and analyzed the semen parameters and sperm DNA fragmentation index(DFI)of the patients.Results:Compared with the baseline,the OS patients showed remarkable increases after 1 and 2 months of treatment in the semen volume([3.07±1.47]vs[3.26±1.26]and[3.30±1.28]ml),sperm concentration([10.96±6.09]vs[16.74±11.15]and[17.56±9.92]×10^(6)/ml,P<0.05),total sperm count([29.78±17.48]vs[52.98±32.07]and[57.67±36.98]×10^(6),P<0.05)and the percentages of progressively motile sperm(PMS)([39.8±11.66]%vs[45.3±14.03]%and[46.42±10.69]%,P<0.05)and morphologically normal sperm(MNS)([1.71±1.07]%vs[1.79±0.91]%and[1.84±0.96]%),and so did the AS patients in PMS([19.23±8.32]%vs[25.46±13.86]%and[27.33±12.88]%,P<0.05).After 3 months of medication,the OS patients exhibited even more significant increases in the semen volume([3.63±1.39]ml)(P<0.05),sperm concentration([20.56±14.7]×10^(6)/ml)(P<0.05),total sperm count([66.35±55.91]×10^(6))(P<0.05),PMS([49.24±13.45]%)(P<0.05)and MNS([2.59±0.93]%)(P<0.05),and so did the AS patients in the semen volume([3.27±1.42]vs[3.85±1.59]ml,P<0.05),PMS([29.11±13.58]%)(P<0.05)and NMS([2.01±1.14]%vs[2.57±1.15]%,P<0.05).In comparison with the baseline,the sperm DFI was not significantly improved at 1 month after treatment,but remarkably decreased at 2 and 3 months in the OS patients([25.87±13.76]%vs[18.66±10.83]%and[16.48±11.46]%,P<0.05)and the AS patients as well([26.40±12.28]%vs[19.35±11.54]%and[15.32±10.89]%,P<0.05).Conclusion:The L-carnitine-astaxanthin compound nutrients Menglankang can significantly improve the semen quality of the patients with idiopathic oligospermia or asthenospermia.

关 键 词：左旋肉碱 虾青素 少精子症 弱精子症 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学] R698.2[医药卫生—基础医学]