盐酸洛美利嗪联合神经生长因子治疗脑出血的疗效观察  

Effect of Lomerizine Hydrochloride Combined with Growth Factor on Clinical Efficacy,Neurological Function and Activities of Daily Living in Patients with Cerebral Hemorrhage

作　　者：苏绍臣[1] 陶艳苹 SU Shaochen;TAO Yanping(Department of Neurosurgery, Jinxiang County People's Hospital 272200;Chenxin Pharmaceutical Co.Ltd,Jining 272073, China)

机构地区：[1]山东省金乡县人民医院神经外科,272200 [2]辰欣药业股份有限公司,272073

出　　处：《中国老年保健医学》2021年第3期66-68,共3页Chinese Journal of Geriatric Care

摘　　要：目的观察盐酸洛美利嗪联合神经生长因子治疗脑出血的临床疗效及其对患者神经功能、日常生活能力的影响。方法选择金乡县人民医院神经外科收治的脑出血患者106例,随机分为研究组(53例)和对照组(53例)。对照组患者接受脑出血常规基础性治疗,研究组患者在对照组基础上给予盐酸洛美利嗪联合神经生长因子治疗,两组患者均持续治疗2周。比较两组患者的临床疗效及治疗前后血肿体积、神经功能缺损评分量表(NIHSS)评分和日常生活能力评定量表(ADL)评分。结果研究组患者治疗总有效率高于对照组(P<0.05)。治疗前两组患者血肿体积、NIHSS评分及ADL评分比较,差异无统计学意义(P>0.05);治疗后研究组患者血肿体积小于对照组,NIHSS评分低于对照组,ADL评分高于对照组(P<0.01)。结论采用盐酸洛美利嗪联合神经生长因子治疗脑出血的临床疗效确切,可有效缩小血肿体积,促进患者神经功能及日常生活能力恢复,安全可靠,可在临床中积极推广应用。Objective To observe the clinical efficacy of lomerizine hydrochloride combined with nerve growth factor in the treatment of cerebral hemorrhage and its influence on patients'nerve function and ability of daily living.Methods A total of 106 patients with cerebral hemorrhage in the nerve shell of Jinxiang County People's Hospital were randomly divided into experimental group(53 cases)and control group(53 cases).Patients in the control group received conventional basic treatment for cerebral hemorrhage,and patients in the study group were treated with lomerizine hydrochloride combined with nerve growth factor on the basis of the control group.Patients in both groups were treated for 2 weeks.To compare the clinical efficacy of the two groups of patients and the volume of hematoma and neurological deficit before and after treatment.Impairment score scale(NIHSS)score and ability of daily living(ADL)score.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).Before treatment,there was no significant difference in hematoma volume,NIHSS score and ADL score between the two groups of patients(P>0.05);after treatment,the blood of the study group.The swelling volume was smaller than the control group,the NIHSS score was lower than that of the control group,and the ADL score was higher than that of the control group(P<0.01).Conclusion The clinical effect of Lomerizine hydrochloride combined with nerve growth factor in the treatment of cerebral hemorrhage is definite,which can effectively reduce the volume of hematoma,promote the recovery of patients'nerve function and daily living ability,and is safe and reliable,it can be actively promoted and applied in clinical practice.

关 键 词：盐酸洛美利嗪 脑出血 神经生长因子 神经功能 

分 类 号：R743.34[医药卫生—神经病学与精神病学]