响应性纳米材料在肿瘤分析中的研究进展  

Progress of Stimuli-responsive Nanomaterials in Tumor Analysis

作　　者：展佳愔 刘然 张晶晶 ZHAN Jia-Yin;LIU Ran;ZHANG Jing-Jing(State Key Laboratory of Analytical Chemistry for Life Science,School of Chemistry and Chemical Engineering,Chemistry and Biomedicine Innovation Center(ChemBIC),Nanjing University,Nanjing 210023,China)

机构地区：[1]南京大学化学化工学院,生命分析化学国家重点实验室,化学和生物医药创新研究院,南京210023

出　　处：《分析化学》2021年第7期1133-1141,共9页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.22004063);江苏省自然科学基金项目(No.20200303);南京大学技术创新基金项目(No.020514913414)资助。

摘　　要：响应性纳米材料在肿瘤相关疾病内源性因素(如pH值、过表达的酶、氧化还原等)或外源性因素(如光、热、磁等)的触发下,可发生结构和性质的改变,从而实现精准的药物递送和成像。不同类型刺激响应性纳米材料在结构、组成及功能等方面存在差异,其应用也不同,如受诱导产生光热效应进行光热治疗、发生结构改变释放信号或药物进行成像或化疗等。为了探讨新型响应性纳米材料的应用潜力,本文对外源光响应性和内源酶响应性纳米材料用于肿瘤相关疾病治疗及生物成像领域的研究进展进行了评述,并对其未来发展方向进行了展望。Under the trigger of endogenous stimuli(such as pH,overexpressed enzymes,redox,etc.)or exogenous stimuli(such as light,temperature,magnetic fields,etc.),stimuli-responsive nanomaterials can change their structures and properties in tumor tissues,so as to achieve precise drug delivery and imaging.Due to the differences in structure,composition and function,these stimuli-responsive nanomaterials have exhibited diverse applications,such as photothermal therapy,chemotherapy or imaging by triggered drug delivery.To explore the potential applications of stimuli-responsive nanomaterials,this review focuses on exogenous light-responsive and/or endogenous enzyme-responsive nanomaterials and summarizes the research progress in the areas of tumor-related therapy and bioimaging in the past few years.

关 键 词：光响应 酶响应 纳米材料 肿瘤治疗 生物成像 评述 

分 类 号：R730.5[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]