运动锻炼对药物依赖者的康复效益及潜在机制  

A Study of Rehabilitation Benefits and Potential Mechanism of Physical Exercise Intervening in Drug Addicts

作　　者：杨管 张秀丽[1,2] 王松涛[1] YANG Guan;ZHANG Xiuli;WANG Songtao(South China Normal University,Guangzhou 510006,China;SCNU-GPBDR Collaborative Research Center of Exercise Training and Drug Rehabilitation,Guangzhou 510006,China)

机构地区：[1]华南师范大学,广东广州510006 [2]华南师范大学-广东省戒毒管理局运动戒毒与康复训练科研合作基地,广东广州510006

出　　处：《中国体育科技》2021年第6期46-52,共7页China Sport Science and Technology

基　　金：广东省司法行政研究课题(GDSFT19029);横向委托课题(341710)。

摘　　要：以正则通路为理论指导,同时结合习惯性运动,通过分析药物依赖者在躯体依赖和心理依赖两个维度的主要临床特征基础上,进而阐述急性有氧运动和长期有氧运动对药物依赖者的康复效益。与此同时,借助功能内稳态理论,进一步指出习惯性力量运动(即抗阻运动)是通过力量运动特异的信号转导通路IGF1-PI3K-Akt-mTOR增强肌肉蛋白质合成,而习惯性耐力运动(即有氧运动)可以通过耐力运动特异的信号转导通路AMPK/PGC-1α提高线粒体活性,即运动锻炼通过这两个潜在作用路径对药物依赖者的康复效益起到积极作用。Combined with habitual exercise,this study takes the normal signal transduction pathway as the theoretical guidance,and expounds the rehabilitation benefits of acute aerobic exercise and long-term aerobic exercise on drug dependent patients,on the basis of analyzing the two dimensions of physical dependence and psychological dependence of drug addicts with main clinical characteristics.At the same time,relying on the theory of Function-Specific Homeostasis(FSH),it is further pointed out that habitual strength exercise(i.e.resistance exercise)enhances muscle protein synthesis through IGF1-PI3K-Akt-mTOR,a signal transduction pathway specific to strength exercise,while habitual endurance exercise(i.e.aerobic exercise)can improve mitochondrial activity through AMPK/PGC-1,a signal transduction pathway specific to endurance exercise;that is to say,exercise would play a positive role in the rehabilitation benefits of drug addicts through these two potential pathways.

关 键 词：药物依赖者 运动锻炼 正则通路 习惯性运动 康复效益 

分 类 号：G804.2[文化科学—运动人体科学]