Metal peroxides for cancer treatment  

作　　者：Jin He Lian-Hua Fu Chao Qi Jing Lin Peng Huang 

机构地区：[1]Marshall Laboratory of Biomedical Engineering,International Cancer Center,Laboratory of Evolutionary Theranostics(LET),School of Biomedical Engineering,Health Science Center,Shenzhen University,Shenzhen,518060,China [2]Key Laboratory of Biorheological Science and Technology,Ministry of Education,College of Bioengineering,Chongqing University,Chongqing,400044,China

出　　处：《Bioactive Materials》2021年第9期2698-2710,共13页生物活性材料（英文）

基　　金：This work is financially supported by the National Key R&D Program of China(2018YFA0704000);the National Natural Science Foundation of China(21807074,51802202,31900945,82071985);Shenzhen Science and Technology Program(KQTD20190929172538530,JCYJ20180507182413022,JCYJ20170412111100742);the Guangdong Province Natural Science Foundation of PhD Start-up Fund(2018A030310574 and 2018A030310566);the Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project(2018B030308003);the Fundamental Research Funds for the Central Universities(2020CDJQY-A060).

摘　　要：In recent years,metal peroxide(MO_(2))such as CaO_(2) has received more and more attention in cancer treatment.MO_(2) is readily decompose to release metal ions and hydrogen peroxide in the acidic tumor microenvironment(TME),resulting metal ions overloading,decreased acidity and elevated oxidative stress in TME.All of these changes making MO_(2) an excellent tumor therapeutic agent.Moreover,by combining MO_(2) with photosensitizers,enzymes or Fenton reagents,MO_(2) can assist and promote various tumor therapies such as photodynamic therapy and chemodynamic therapy.In this review,the synthesis and modification methods of MO_(2) are introduced,and the representative studies of MO_(2)-based tumor monotherapy and combination therapy are discussed in detail.Finally,the current challenges and prospects of MO_(2) in the field of tumor therapy are emphasized to promote the development of MO_(2)-based cancer treatment.

关 键 词：Metal peroxide Metal ions overloading Oxidative stress Combination therapy Cancer treatment 

分 类 号：R730.5[医药卫生—肿瘤]