动脉自旋标记对胶质瘤复发与放射性脑损伤鉴别诊断价值的Meta分析  

Diagnostic value of arterial spin labeling in differentiating glioma recurrence from radiation-induced brain injury:a Meta-analysis

作　　者：杜泳荟 郭志伟[1] 王涛[1] 蒋依 母其文[1] DU Yonghui;GUO Zhiwei;WANG Tao;JIANG Yi;MU Qiwen(Imaging Institute of Rehabilitation and Imaging of Brain Function,the Second Clinical Medical College of North Sichuan Medical College/Nanchong Central Hospital,Nanchong 637000,China;Chengdu Second People’s Hospital,Chengdu 610017,China)

机构地区：[1]川北医学院第二临床医学院南充市中心医院脑功能康复与成像研究所,四川南充637000 [2]成都市第二人民医院,四川成都610017

出　　处：《中国实用神经疾病杂志》2021年第11期966-971,共6页Chinese Journal of Practical Nervous Diseases

基　　金：四川省科技厅课题(编号:21YZTG0028);南充市科技局项目(编号:18SXHZ0079)。

摘　　要：目的评价动脉自旋标记(ASL)灌注成像鉴别胶质瘤复发与放射性脑损伤的诊断价值。方法检索英文数据库(PubMed、Embase、WOS和Cochrane图书馆)及中文数据库(CNKI、万方和维普)中采用ASL鉴别诊断胶质瘤术后复发和放射性脑损伤的临床研究,检索时间为建库至2020-12。两名研究者独立筛选文献,提取相关文献的临床特征信息。纳入文献的质量评价采用诊断准确性研究质量评价工具QUADAS-2。应用Meta-Disc 1.4、Stata14.0及RevMan5.3软件进行Meta分析及图表制作。结果最终纳入文献16篇,包括复发组360例,放射性脑损伤组265例。Meta分析显示,ASL鉴别胶质瘤复发和放射性脑损伤的合并灵敏度、特异度、阳性似然比、阴性似然比、诊断比值比分别为0.82(95%CI 0.75~0.88)、0.87(95%CI 0.78~0.92)、6.2(95%CI 3.6~10.7)、0.20(95%CI 0.14~0.29)、30(95%CI 14~67),曲线下面积为0.91(95%CI 0.88~0.93)。结论ASL在区分胶质瘤术后复发和放射性脑损伤方面具有良好的诊断价值。Objective To investigate the diagnostic value of arterial spin labeling(ASL)perfusion imaging in differentiating glioma recurrence from radiation-induced brain injury.Methods PubMed,Embase,Cochrane Library,Web of Science,CNKI,Wanfang Data,and VIP were searched for studies on the diagnostic value of ASL in differentiating glioma recurrence from radiation-induced brain injury published up to December 2020.Two researchers independently screened the literature and extracted the clinical characteristic information.The quality of included studies was evaluated by the Diagnostic Test Accuracy Study Quality Evaluation Scale-2(QUADAS-2).All statistics analyses were performed using Meta-Disc1.4,Stata14.0 and RevMan5.3 software.Results A total of 16 studies involving 360 recurrence lesions and 265 radiation-induced brain injury lesions were included.The results of this meta-analysis showed that the pooled sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,and diagnostic odds ratio were 0.82(95%CI:0.75-0.88),0.87(95%CI:0.78-0.92),6.2(95%CI:3.6-10.7),0.20(95%CI:0.14-0.29),30(95%CI:14-67),respectively.The area under curve was 0.91(95%CI:0.88-0.93).Conclusion ASL has good value in differentiating glioma recurrence from radiation-induced brain injury.

关 键 词：胶质瘤 复发 放射性脑损伤 动脉自旋标记 META分析 

分 类 号：R730.264[医药卫生—肿瘤]