Zn-contained mussel-inspired film on Mg alloy for inhibiting bacterial infection and promoting bone regeneration  

作　　者：Feng Peng Shi Cheng Ruiying Zhang Mei Li Jielong Zhou Donghui Wang Yu Zhang 

机构地区：[1]Department of Orthopedics,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guangdong 510080,China [2]School of Materials Science and Engineering,Hebei University of Technology,Tianjin 300130,China

出　　处：《Regenerative Biomaterials》2021年第1期10-24,共15页再生生物材料（英文版）

基　　金：This study was supported by the National Key Research and Development Project(2017YFB0702600,2016YFB0700800);China Postdoctoral Science Foundation(2019M662830);National Natural Science Foundation of China(51901239);Natural Science Foundation of Guangdong Province,China(Grant No.2020A1515011447);The Joint Fund of Ministry of Education for Equipment Pre-research(No.6141A02022632);Scientific and Technological Projects of Guangzhou,China(Grant No.202002030283).

摘　　要：Infection and insufficient osteointegration are the main causes of orthopedic implant failure.Furthermore,activating favorable inflammation response is vital to the fast osteointegration of implants.Therefore,endowing the implants with multifunctions(antibacterial,anti-inflammation,and pro-osteointegration)is a promising strategy to improve the performance of orthopedic implants.In this study,a Zn-contained polydopamine(PDA)film was fabricated on AZ31 alloy.The film possessed a stable Zn ion release in 14 days.The results of electrochemical analysis implied the favorable corrosion protection of the film,and thus,leading to a suitable hemolysis ratio(below 1%).The in vitro antibacterial assessment revealed that the film exhibited excellent resistance against Staphylococcus aureus(nearly 100%),which can be ascribed to the release of Zn ions.The cell-culture evaluation revealed that the extract of Zn-contained PDA-coated sample can activate RAW264.7 polarization to an anti-inflammatory phenotype,as well as enhance the osteogenic dif-ferentiation ability of MC3T3-E 1.Additionally,the femoral osteomyelitis model indicated that the as-prepared film had a high antibacterial capability at early stage of the implantation,and showed better osteogenesis and osteointegration after 8 weeks of implantation.With favorable antibacte-rial,anti-inflammation,and pro-osteogenesis abilities,the novel designed Zn-contained PDA film is promising to be used in Mg-based orthopedic implants.

关 键 词：magnesium alloy zinc POLYDOPAMINE antibacte rial ANTI-INFLAMMATION osteointe gration 

分 类 号：TG146.22[一般工业技术—材料科学与工程]