硫酸羟氯喹联合白芍总苷肽治疗口腔糜烂型扁平苔藓的临床应用  

Clinical application of Hydroxychloroquine Sulfate combined with Total Glycosides of White Paeony Root in the treatment of oral erosive lichen planus

作　　者：葛蓓蓓 宋勇 Ge Beibei;Song Yong(Department of Stomatology,the Affiliated Suqian Hospital of Xuzhou Medical University,Suqian 223800,China)

机构地区：[1]徐州医科大学附属宿迁医院口腔科,江苏宿迁223800

出　　处：《中华临床医师杂志（电子版）》2021年第1期32-36,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨硫酸羟氯喹联合白芍总苷治疗口腔糜烂型扁平苔藓的临床优势。方法收集2018年1月至2019年5月徐州医科大学附属宿迁医院口腔门诊治疗口腔糜烂型扁平苔藓患者33例,采用密封不透明信封随机抽取的方法,将33例患者分为2组,所有患者均局部使用曲安奈德口腔软膏。治疗组17例给予硫酸羟氯喹片200 mg,口服,早晚1次;同时服用白芍总苷胶囊,每次0.6 g,早晚1次。对照组16例仅给予硫酸羟氯喹片200 mg,口服,早晚1次。治疗6个月,观察2组治疗效果及并发症情况。结果治疗组17例中,显效12例,有效4例,无效1例,总有效率为94.12%;对照组16例中,显效9例,有效5例,无效2例,总有效率为87.50%;两组治疗6个月总有效率比较,差异有统计学意义(χ^(2)=6.415,P=0.048)。两组显效患者中,女性占比较高,治疗组占58.3%,对照组占66.7%。在治疗中,治疗组非特异性皮疹发生率(5.88%)低于对照组(18.75%),差异有统计学意义(χ^(2)=0.985,P=0.046)。结论在局部均使用曲安奈德口腔软膏的基础上,全身运用硫酸羟氯喹联合白芍总苷治疗口腔糜烂型扁平苔藓取得了预期的临床效果,并发症较少,患者的耐受性和依从性较好,值得在临床中推广。Objective To assess the clinical value of Hydroxychloroquine Sulfate combined with Total Glycosides of White Paeony Root in the treatment of oral erosion lichen planus.Methods A total of 33 patients with oral lichen planus who were treated in the Stomatological Outpatient Department of Suqian Hospital Affiliated to Xuzhou Medical University from January 2018 to May 2019 were collected.The 33 patients were randomly divided into either a control group or a treatment group with sealed opaque envelopes.All the patients were given Triamcinolone Acetonide Oral Ointment.The treatment group(n=17)was additionally given 200 mg Hydroxychloroquine Sulfate Tablets orally,twice daily and Total Gglycosides of White Paeony Root Capsules,0.6 g each time,twice daily.The control group(n=16)was only given 200 mg Hydroxychloroquine Sulfate Tablets orally,twice daily.The treatments lasted 6 months.The therapeutic effects and complications of the two groups were observed.Results In the treatment group,12 cases achieved significant improvement,4 achieved improvement,and 1 had no improvement,with a total effective rate of 94.12%.In the control group,9 cases achieved significant improvement,5 achieved improvement,and 2 had no improvement,with a total effective rate of 87.50%.There was a statistically significant difference in the total effective rate between the two groups after 6 months of treatment(χ^(2)=6.415,P=0.048).In the two groups,women accounted for more than 58.3%in the treatment group and 66.7%in the control group.During the treatment,the incidence of non-specific rash in the treatment group(5.88%)was significantly lower than that in the control group(18.75%;χ^(2)=0.985,P=0.046).Conclusion Based on the topical application of Triamcinolone Acetonide Oral Ointment,the systemic application of Hydroxychloroquine Sulfate combined with Total Glycosides of White Paeony Root in the treatment of oral erosion lichen planus has achieved the expected clinical effect,with fewer complications and good tolerance and compliance in patients,w

关 键 词：羟氯喹 白芍总苷 糜烂型 口腔扁平苔藓 

分 类 号：R781.5[医药卫生—口腔医学]