食管癌CT灌注成像与病理的相关性分析  

Correlation between CT perfusion imaging and pathology in esophageal carcinoma

作　　者：李俊萍 赵如森 张桂芝 齐玉芳 李兆栋 LI Jun-ping;ZHAO Ru-sen;ZHANG Gui-zhi;QI Yu-fang;LI Zhao-dong(Zibo Municipal Hospital,Zibo 255400,China)

机构地区：[1]淄博市市立医院肿瘤科,淄博255400 [2]淄博市市立医院放疗科,淄博255400 [3]淄博市市立医院影像科,淄博255400

出　　处：《武警后勤学院学报（医学版）》2021年第5期15-19,共5页Journal of Logistics University of PAP（Medical Sciences）

基　　金：国家卫生计生委医药卫生科技发展研究中心基金资助项目(W2015PM071)。

摘　　要：【目的】探讨食管癌CT灌注成像与病理分期、肿瘤组织内免疫蛋白表达的关系。【方法】对72例食管癌患者进行CT灌注扫描,分析CT灌注成像参数血流量(blood flow,BF)、血容量(blood volume,BV)、平均通过时间(mean transit time,MTT)、表面通透性(permeability surface,PS)与病理分期及CD34、Ki67蛋白表达之间的关系。【结果】不同肿瘤类型、组织分化程度、肿瘤浸润深度与病变部位患者的CT灌注成像参数BV、BF、MTT、PS值差异无统计学意义(P>0.0.5);是否有淋巴结转移与CT灌注成像参数PS值差异有统计学意义(P<0.05),但与BV、BF和MTT比较差异无统计学意义(P>0.05)。食管癌组患者TN分期诊断T分期准确率为76.39%(55/72),N分期准确率为70.83%(51/72),其对食管癌TN分期的诊断与病理检查具有较好的一致性。食管癌组CD34蛋白表达阳性率为68.05%,Ki67蛋白表达高表达率为61.11%,均显著高于对照组(P<0.05)。【结论】食管癌CT灌注成像在食管鳞癌术前分期诊断中具有一定优势,能够在活体上间接反映出食管癌的生物学行为和患者预后。【Objective】To explore the correlation between CT perfusion imaging and pathological staging and immunoprotein expression in tumor tissues of esophageal carcinoma.【Methods】CT perfusion scanning was performed in 72 patients with esophageal cancer to analyze the relationship between CT perfusion imaging parameters such as blood flow(BF), blood volume(BV), mean passage time(MTT), surface permeability(PS), pathological stage and expression of CD34 and Ki67 proteins.【Results】There were no significant differences in CT perfusion imaging parameters BV, BF, MTT and PS between the patients with different types of tumors, degree of tissue differentiation, depth of tumor invasion and lesion sites(P > 0.5). There was a significant difference in PS between the patients with lymph node metastasis and those without lymph node metastasis(P < 0.05), but there was no significant difference in BV, BF and MTT(P > 0.05). The accuracy of CT perfusion imaging in the diagnosis of TN staging in esophageal cancer patients was 76.39%(55/72)and 70.83%(51/72), respectively. The accuracy of CT perfusion imaging in the diagnosis of TN staging in esophageal cancer patients was in good agreement with pathological examination. The positive rate of CD34 protein expression was 68.05%, the positive and strong positive rate was 61.11% in esophageal cancer group,which was significantly higher than that in the control group(P < 0.05).【Conclusion】CT perfusion imaging has certain advantages in the preoperative staging diagnosis of esophageal squamous cell cancer.This can indirectly reflect the biological behavior and prognosis of esophageal cancer in vivo.

关 键 词：食管癌 灌注成像 CD34蛋白 KI67蛋白 微血管密度 

分 类 号：R361[医药卫生—病理学]