VETC癌巢型肝细胞癌的研究进展  

Research progress of VETC carcinoma nest-type hepatocellular carcinoma

作　　者：杨建荣[1] 刘天奇[1] 郑树森 董小锋[1] YANG Jian-rong;LIU Tian-qi;ZHENG Shu-sen(Department of Hepatobiliary,Pancreas and Spleen Surgery,Guangxi Academy of Medical Sciences,the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西医学科学院,广西壮族自治区人民医院肝胆胰脾外科,南宁530021 [2]浙江大学附属第一医院肝胆胰外科,杭州310000

出　　处：《中国临床新医学》2021年第6期529-533,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家自然科学基金项目(编号:81560406)。

摘　　要：肝癌的复发转移是影响肝癌患者预后的关键。血管包绕肿瘤细胞巢(VETC)癌巢型肝细胞癌的转移方式无法用上皮-间质转化(EMT)理论来解释,其可以内皮细胞包绕肿瘤细胞团的形式发生整体转移,转移过程中肿瘤细胞不会发生EMT,VETC癌巢型肝细胞癌更易发生转移,转移效率更高,术后更易复发,预后更差。该文对VETC癌巢型肝细胞癌的分型、分子学特征、诊断、治疗及预后等进行评价和介绍,从而提高临床医师及研究人员对该类肝癌诊治的认识。Relapse and metastasis are the key factors affecting the prognosis of patients with hepatocellular carcinoma(HCC).The metastasis mechanisms of vessels encapsulated tumor clusters(VETC)carcinoma nest-type HCC can not be explained by the theory of epithelial-to-mesenchymal transition(EMT).In VETC carcinoma nest-type HCC,tumor cells do not metastasize through EMT,but metastasize to other organs in carcinoma nest form in which VETC carcinoma nest-type HCC is encapsulated by endothelial cells.VETC carcinoma nest-type HCC is more likely to have metastasis and higher metastatic efficiency,and is more likely to relapse after operation,resulting in a worse prognosis.This paper evaluates and introduces the classification,molecular characteristics,diagnosis,treatment and prognosis of VETC carcinoma nest-type HCC,so as to improve the understanding of clinicians and researchers on the diagnosis and treatment of VETC carcinoma nest-type HCC.

关 键 词：肝细胞癌 血管包绕肿瘤细胞巢 诊断 治疗 预后 

分 类 号：R735.7[医药卫生—肿瘤]