Erythromycin loaded by tetrahedral framework nucleic acids are more antimicrobial sensitive against Escherichia coli(E.coli)  

作　　者：Yue Sun Yuhao Liu Bowen Zhang Shirong Shi Tao Zhang Dan Zhao Taoran Tian Qirong Li Yunfeng Lin 

机构地区：[1]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu,610041,China [2]College of Biomedical Engineering,Sichuan University,Chengdu,610041,China

出　　处：《Bioactive Materials》2021年第8期2281-2290,共10页生物活性材料（英文）

基　　金：This study was funded by the National Key R&D Program of China[2019YFA0110600]and National Natural Science Foundation of China [81970916, 81671031].

摘　　要：Erythromycin is a commonly used broad-spectrum antibiotic,but resistance to this antibiotic makes its use less effective.Considerable efforts,beside finding alternatives,are needed to enhance its antimicrobial effect and stability against bacteria.Tetrahedral framework nucleic acids(tFNAs),a novel delivery vehicle with a three-dimensional nanostructure,have been studied as a carrying platform of antineoplastic drugs.In this study,the use of tFNAs in delivering erythromycin into Escherichia coli(E.coli)was investigated for the first time.The tFNAs vehicle increased the bacterial uptake of erythromycin and promoted membrane destabilization.Moreover,it increased the permeability of the bacterial cell wall,and reduced drug resistance by improving the movement of the drug across the membrane.The tFNAs-based delivery system enhanced the effects of erythromycin against E.coli.It may therefore provide an effective delivery vehicle for erythromycin in targeting antibiotic-resistant bacteria with thick cell wall.

关 键 词：Tetrahedral framework nucleic acids Drug delivery system Escherichia coli Drug penetration disorder ERYTHROMYCIN 

分 类 号：R318[医药卫生—生物医学工程] R37[医药卫生—基础医学]