青少年睡眠与C-反应蛋白及胰岛素代谢的相关性  

Association between sleep with C-reactive protein and insulin metabolism in adolescents

作　　者：唐玉青 李丽雯[1] 吕佳骏 陈仪婷 WANG Xiaobin 李生慧[1] TANG Yuqing;LI Liwen;LYU Jia-jun;CHEN Yiting;WANG Xiaobin;LI Shenghui(School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai(200025),China)

机构地区：[1]上海交通大学医学院公共卫生学院,上海200025 [2]Division of General Pediatrics&Adolescent Medicine,Department of Pediatrics,Johns Hopkins University School of Medicine

出　　处：《中国学校卫生》2021年第6期819-822,828,共5页Chinese Journal of School Health

基　　金：国家自然科学基金项目(81874266,81673183);上海市科学技术委员会科技创新行动计划研究专项(18411951600)。

摘　　要：目的探讨青少年睡眠状况与C-反应蛋白(CRP)异常及高胰岛素血症的相关性,为代谢异常相关疾病的预防提供参考。方法基于中国安徽代谢综合征研究,共选取653名12~19岁青少年,分析晨起时间、就寝时间、睡眠呼吸障碍(SDB)与CRP异常及高胰岛素血症之间的相关性。结果晨起时间晚与空腹高胰岛素血症发生风险上升相关(OR=1.68,95%CI=1.03~2.75)。就寝时间晚(OR=1.96,95%CI=1.29~2.99)与餐后2 h高胰岛素血症发生风险上升呈正相关。在高CRP浓度状态下,晨起时间晚和就寝时间晚与高胰岛素血症相关性的效应强度增大,且SDB与高胰岛素血症呈正相关。结论晨起时间晚和就寝时间晚可能是青少年高胰岛素血症的危险因素。高浓度CRP可能会使睡眠问题所致的高胰岛素血症的发生风险进一步提高。青少年晨起及就寝时间应尽可能提早。Objective To explore the relationship of sleep with C-reactive protein(CRP)abnormality and hyperinsulinemia in adolescents,and to provide reference for early prevention of metabolic disorders.Methods Based on the Chinese Metabolic Syndrome Cohort Study in Anhui Province,a total of 653 adolescents aged 12 to 19 were selected to examine the relationship between wakeup time,bedtime,sleep disordered breathing(SDB)and CRP abnormality as well as hyperinsulinemia.Results Later wakeup time(OR=1.68,95%CI=1.03-2.75)was positively correlated with a higher risk of fasting hyperinsulinemia.Late bedtime(OR=1.96,95%CI=1.29-2.99)was associated with 2 h postprandial hyperinsulinemia.Among those with high CRP concentration,late wakeup time and late bedtime were positely associated with hyperinsulinemia than those with normal CRP concentration;and the correlation between SDB and hyperinsulinemia was observed.Conclusion Later wakeup and late bedtime may be risk factors for hyperinsulinemia in adolescents.High concentrations of CRP may further increase the risk of hyperinsulinemia,a condition associated with sleep problems.Teenagers should get up and go to bed as early as possible.

关 键 词：睡眠 C反应蛋白质 胰岛素 回归分析 青少年 

分 类 号：R179[医药卫生—妇幼卫生保健] R446[医药卫生—公共卫生与预防医学]