A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse  

作　　者：Mengjie Xie Junlang Li Sichen Zhang Dashuai Zhu Xuan Mei Zhenzhen Wang Xiao Cheng Zhenhua Li Shaowei Wang Ke Cheng 

机构地区：[1]The Key Laboratory of Geriatrics,Beijing Institute of Geriatrics,Beijing Hospital,National Center of Gerontology,National Health Commission,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,PR China [2]Department of Molecular Biomedical Sciences,North Carolina State University,Raleigh,NC,27607,USA [3]Joint Department of Biomedical Engineering,North Carolina State University&University of North Carolina at Chapel Hill,Raleigh,NC,27607,USA [4]Department of Gynecology and Obstetrics,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,PR China

出　　处：《Bioactive Materials》2021年第6期1777-1788,共12页生物活性材料（英文）

摘　　要：Current contraceptive methods come with a number of drawbacks,including low efficacy,in the case of commercial contraceptive gels,and a reduction in the quality of sexual intercourse,in the case of condoms.Adding pharmacologically-active agents to contraceptive gels holds the potential to improve sexual experience,and hardbor safety and hygiene.In this study,we fabricated a carbomer-based contraceptive gel consisting of three agents:tenofovir,gossypol acetate,and nitroglycerin(TGN),with pH adjusted to 4.5(to be compatible with the vagina).In vitro,the gossypol component of the contraceptive gel proved to be an effective spermicide.When the concentration of gossypol acetate was 10 mg/ml,the spermicidal ability reached 100%after 30 s.In addition,tenofovir in the gel significantly inhibited lentiviral transfection efficiency in cell-containing media.In 6 pairs of rats,the gel successfully prevented all females from conceiving after successful mating.Moreover,increased sexual frequency and enhanced erection,which were promoted by the nitroglycerin in the components,were observed in male rats that had the gel applied to their penises.This novel TGN contraceptive gel yielded a higher contraceptive success rate than that of the commercial contraceptive gel(Contragel®).In addition,it has the added benefits to prevent sexually transmitted diseases and improve male libido and erectile function during sexual intercourse.Combining three FDA-approved and marketed agents together,our trifunctional TGN gel has a great potential for further translation and commercialization.

关 键 词：CONTRACEPTIVE HYDROGEL ANTI-VIRAL LIBIDO Erectile function 

分 类 号：R169.41[医药卫生—公共卫生与预防医学] TQ427.26[化学工程]